NrsZ small RNA

NrsZ (nitrogen regulated small RNA) is a bacterial small RNA found in the opportunistic pathogen Pseudomonas aeruginosa PAO1. Its transcription is induced during nitrogen limitation by the NtrB/C two-component system (an important regulator of nitrogen assimilation and swarming motility) together with the alternative sigma factor RpoN ( a global regulator involved in nitrogen metabolism). NrsZ by activating rhlA (a gene essential for rhamnolipids synthesis) positively regulates the production of rhamnolipid surfactants needed for swarming motility.^[1]

NrsZ sRNA
Predicted secondary structure and sequence conservation of NrsZ small RNA
Identifiers
Rfam	RF02695
Other data
Domain(s)	Bacteria
GO	GO:0071978
SO	SO:0000370
PDB structures	PDBe

See also

• Pseudomonas sRNA
• SrbA sRNA
• AsponA antisense RNA

References

1. Wenner N, Maes A, Cotado-Sampayo M, Lapouge K (April 2014). "NrsZ: a novel, processed, nitrogen-dependent, small non-coding RNA that regulates Pseudomonas aeruginosa PAO1 virulence". Environmental Microbiology. 16 (4): 1053–1068. doi:10.1111/1462-2920.12272. PMC 4253122. PMID 24308329.