Nicotine polacrilex

Nicotine polacrilex is nicotine bound to an ion-exchange resin (polymethacrylic acid, such as Amberlite IRP64, Purolite C115HMR or Doshion P551).^[4] It is added to gum and hard lozenges used for nicotine replacement therapy in smoking cessation,^[5] such as in the Nicorette range of products. The use of the polymer as a delivery system maximizes the amount of nicotine released and absorbed by the oral mucosa. 80 to 90 percent of the nicotine released from the gum is absorbed by the mouth. Side effects of the gum include bad taste, nausea, dyspepsia, and stomatitis.

Nicotine polacrilex

Clinical data
Trade names	Nicorette
License data	US DailyMed: Nicotine polacrilex
Routes of administration	By mouth
ATC code	None
Legal status
Legal status	UK: General sales list (GSL, OTC)[1][2] US: OTC[3] EU: OTC SE: OTC
Identifiers
UNII	6M3C89ZY6R