Neuromedin B receptor

The neuromedin B receptor (NMBR), now known as BB₁ ^[4] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.^[5] In humans, this protein is encoded by the NMBR gene.

NMBR
Identifiers
Aliases	NMBR, BB1, NMB-R, neuromedin B receptor, BB1R, BRS1
External IDs	OMIM: 162341; MGI: 1100525; HomoloGene: 20560; GeneCards: NMBR; OMA:NMBR - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.1 Start 142,058,330 bp[1] End 142,147,122 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis prefrontal cortex olfactory zone of nasal mucosa ganglionic eminence right uterine tube caudate nucleus gonad putamen nucleus accumbens n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled peptide receptor activity signal transducer activity G protein-coupled receptor activity bombesin receptor activity Cellular component integral component of plasma membrane membrane integral component of membrane plasma membrane cytosol Biological process phospholipase C-activating G protein-coupled receptor signaling pathway bombesin receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4829 18101 Ensembl ENSG00000135577 ENSMUSG00000019865 UniProt P28336 O54799 RefSeq (mRNA) NM_002511 NM_001324307 NM_001324308 NM_008703 RefSeq (protein) NP_001311236 NP_001311237 NP_002502 NP_032729 Location (UCSC) Chr 6: 142.06 – 142.15 Mb n/a PubMed search [2] [3]
Wikidata
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Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.^[6]