Neuregulin 4
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[5][6][7]
NRG4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | NRG4, HRG4, neuregulin 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 610894; MGI: 1933833; HomoloGene: 12921; GeneCards: NRG4; OMA:NRG4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.[7]
Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[8]
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