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Nesmith is an unincorporated community in Williamsburg County, South Carolina, United States. It was a station on the Seaboard Air Line Railroad (now CSX Transportation) line which was built about 1912. Today it consists of a post office, fire station, and a country store, serving a large rural area which depends on agriculture and logging. Black Mingo Creek flows alongside the hamlet.
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The community was named after the Nesmith family. The Gamble House was listed on the National Register of Historic Places in 2006.[1]
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