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Greek geneticist and molecular biologist From Wikipedia, the free encyclopedia
Nektarios N. Tavernarakis (Greek: Νεκτάριος Ν. Ταβερναράκης) is a Greek bioscientist, who studies Ageing, Cell death, and Neurodegeneration.[1][2] He is currently Distinguished Professor of Molecular Systems Biology at the Medical School of the University of Crete, and the chairman of the board of directors at the Foundation for Research and Technology, in Heraklion, Crete, Greece. He is also the founder and first director of the Graduate Program in Bioinformatics of the University of Crete Medical School, and has served as director of the Institute of Molecular Biology and Biotechnology, where he is heading the Neurogenetics and Ageing laboratory. He was elected vice president of the European Research Council (ERC) in 2020,[3] and chairman of the European Institute of Innovation and Technology (EIT) governing board and executive committee in 2022.[4]
Nektarios Tavernarakis | |
|---|---|
Νεκτάριος Νικολάου Ταβερναράκης | |
Nektarios Tavernarakis at the Foundation for Research & Technology in Heraklion Crete, Greece (ca. 2020) | |
| Born | May 2, 1967 |
| Nationality | Greek  |
| Citizenship | Greek |
| Education | BSc: Biology, Aristotle University of Thessaloniki (1989) PhD: Molecular Genetics, University of Crete (1995) |
| Alma mater | Aristotle University of Thessaloniki, Thessaloniki, Greece |
| Known for | Ageing, Necrosis, Neurodegeneration |
| Awards | European Research Council (ERC) Advanced Investigator grant award (twice, in 2008 and 2016) European Research Council (ERC) Proof of Concept grant award (2016) EMBO Young Investigator award (2002) Academy of Athens BioMedical Research Award (2014) Alexander von Humboldt Friedrich Wilhelm Bessel research award (2007) Galien Scientific Research Award (2017) Helmholtz International Fellow Award (2017) Human Frontier Science Program (HFSP) long-term postdoctoral fellowship (1996) Bodossaki Foundation Excellence Award (2024) Bodossaki Foundation Scientific Prize for Medicine and Biology (2005) Foundation for Research and Technology Research Excellence award (2007) Empeirikeion Foundation Academic Excellence Prize (2012) |
| Scientific career | |
| Fields | Biology, Cell Biology, Ageing, Neurodegeneration, Systems Biology, Metabolism |
| Institutions | Foundation for Research & Technology – Hellas (FORTH), Institute of Molecular Biology and Biotechnology (IMBB) University of Crete, Medical School |
| Thesis | The yeast transcriptional activator Gcn4p: Expression and function (1995) |
| Website | www |
| Notes | |
Member of the Academy of Athens, the German National Academy of Sciences-Leopoldina, the European Academy of Sciences, the EMBO, Academia Europaea, & the European Academy of Sciences and Arts. Fellow of the AAAS. Fellow of the Royal Society of Biology. Chairman of the EIT Governing Board. Vice President of the ERC Scientific Council. | |
Nektarios Tavernarakis was born and grew up in Megali Vrisi,[5] a small village in the municipality of Gortyna, about 30 Km to the south of Heraklion, and graduated with honours from the 1st High School of Heraklion (Kapetanakeio).[6]
Nektarios Tavernarakis completed his undergraduate studies at the Department of Biology of the Aristotle University, in Thessaloniki, Greece (graduated with honours in 1989), and obtained his PhD degree from the Department of Biology of the University of Crete, in Heraklion, Greece, having received the best PhD Thesis Award. He trained as a postdoctoral researcher at the Department of Molecular Biology & Biochemistry of Rutgers University in New Jersey, USA. He has made notable contributions relevant to cell death, neurodegeneration and ageing, documented in the scientific literature.[7][8]
In 2020, Nektarios Tavernarakis was elected vice president of the European Research Council (ERC),[3] and in 2022, he became chairman of the European Institute of Innovation and Technology (EIT) Governing Board,[4] He is a member of the European Molecular Biology Organization (EMBO),[9] the European Academy of Sciences (EurASc),[10] Academia Europaea,[11] the German National Academy of Sciences-Leopoldina[12] and the European Academy of Sciences and Arts (EASA).[13] He is also a corresponding member of the Academy of Athens,[14] and a Fellow of the American Association for the Advancement of Science (AAAS).[15]
His work has received several prominent awards and scientific prizes, including two European Research Council (ERC) Advanced Investigator grant awards (in 2008 and 2016),[16][17] a European Research Council (ERC) Proof of Concept grant award,[18] the EMBO Young Investigator award, the International Human Frontier Science Program (HFSP) long-term postdoctoral fellowship, the BioMedical Research Award of the Academy of Athens, the Valergakis Post-Graduate Award of the Hellenic University Club of New York, the Galien Scientific Research Award,[19] the Helmholtz International Fellow Award,[20] the Alexander von Humboldt Foundation, Friedrich Wilhelm Bessel research award, the Research Excellence award of the Foundation for Research and Technology, and the Empeirikeion Foundation Academic Excellence Prize, among others. He is also the recipient of the Excellence Award,[21] and the Scientific Prize for Medicine and Biology,[22] of the Bodossaki Foundation, which are two of the most competitive scientific distinctions for Greeks, in Greece and abroad. He is the only Greek scientist to have been awarded both these prestigious prizes.
Nektarios Tavernarakis has contributed to the elucidation of the molecular mechanisms of necrotic cell death and neurodegeneration, the interplay between cellular metabolism and ageing, the mechanisms of sensory transduction and integration by the nervous system.[23][24] He has also contributed towards the development of novel genetic tools for biomedical research, including an RNA interference (RNAi) method that allows efficient knockdown of neuronal genes.[25] His PhD Thesis research focused on the expression and function of key stress response transcriptional activators in the yeast Saccharomyces cerevisiae, and provided original insights on the regulation of these activators by nutrient limitation, and the role of DNA in determining interactions between transcription factors and co-factors.[26] His laboratory at IMBB was the first to commence Caenorhabditis elegans research in Greece. He has published more than 250 papers in peer-reviewed scientific journals, such as Nature. His work has received more than 55,000 citations.[27] Among the notable discoveries of his team are the sophisticated molecular mechanisms, by which diverse physiological signals are integrated to modulate cellular mitochondrial content,[28] protein synthesis,[29][30] and energy homeostasis during ageing.[31] These studies revealed intricate signaling pathways that coordinate mitophagy and mitochondrial biogenesis, to determine the number of mitochondria in cells, under stress and during ageing.[32][33][34] Work from his lab implicated autophagy,[35] lysosomal function,[36][37] endocytosis,[38] intracellular calcium homeostasis[39] and specific proteolytic enzymes[40] as major contributors to necrosis and neurodegeneration. His group developed, for the first time, experimental heat stroke models; and identified mechanisms protecting against heat cytotoxicity and other necrotic insults.[41] He has isolated and characterized specific ion channels, involved in proprioception and coordinated locomotion,[42] in dopaminergic signalling and associative learning.[43] His team was the first to delineate the role of autophagy in the regulation of synaptic plasticity and behaviour under nutrient deprivation and stress.[44][45] Work in his laboratory also led to the identification of specific nuclear autophagy mediators and the characterization of their role in ageing and germline immortality.[46][47]
Nektarios Tavernarakis is married and the father of two daughters. He is a licensed radio amateur, active mainly in the VHF, UHF and SHF radio bands. His callsign is SV9IOR.[48][49]
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