Nedocromil

Nedocromil sodium is a medication considered as mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade, and as an eye drop under the brand name Alocril.^[1][2] The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators like albuterol or other well-known inhaler medications. Liquid preparations of nedocromil are available in the UK under the name Rapitil for use for allergic eye reactions.^[3] Nedocromil sodium has been shown to be effective in alleviating symptoms of allergic conjunctivitis.^[4]

Nedocromil

Clinical data
Trade names	Alocril
AHFS/Drugs.com	Monograph
MedlinePlus	a601243
Routes of administration	Inhalation and eye drops
ATC code	R01AC07 (WHO) R03BC03 (WHO), S01GX04 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	89%
Metabolism	not metabolized
Elimination half-life	~3.3 hours
Excretion	excreted unchanged
Identifiers
IUPAC name 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
CAS Number	69049-73-6 Y
PubChem CID	50294
IUPHAR/BPS	7607
DrugBank	DB00716 Y
ChemSpider	45608 Y
UNII	0B535E0BN0
KEGG	D05129 Y
ChEBI	CHEBI:7492 Y
ChEMBL	ChEMBL746 Y
CompTox Dashboard (EPA)	DTXSID7023356
ECHA InfoCard	100.233.208
Chemical and physical data
Formula	C19H17NO7
Molar mass	371.345 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC
InChI InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) Y Key:RQTOOFIXOKYGAN-UHFFFAOYSA-N Y
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Nedocromil is classified as a benzopyrone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008 because it used CFCs as propellant.^[5]

See also

• Cromolyn

References

Media related to Nedocromil at Wikimedia Commons

1. "ALOCRIL Product Information". Allergan. Archived from the original on 8 May 2013. Retrieved 17 May 2013.
2. Allen H. Dajani S (ed.). "ALOCRIL (nedocromil sodium) solution/ drops". DailyMed. U.S. National Institutes of Health. Retrieved 17 May 2013.
3. "Nedocromil eye drops". Patient.info. 2007-02-02. Retrieved 2009-08-04.
4. Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis" (PDF). The Cochrane Database of Systematic Reviews. 2015 (6): CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMC 10616535. PMID 26028608.
5. "Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil". U.S. Food and Drug Administration. 13 April 2010. Archived from the original on 2 February 2012.