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Naftifine hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (topical fungal infections).
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| Clinical data | |
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| Trade names | Exoderil, Naftin |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a688020 |
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| Chemical and physical data | |
| Formula | C21H21N |
| Molar mass | 287.406 g·mol−1 |
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Naftifine was invented at the Sandoz Research Institute in Vienna, Austria. It was the first successful antifungal medication of the allylamine class.[1]
Naftifine has triple action: antifungal, antibacterial, and anti-inflammatory. Its fungistatic activity is believed to be based on inhibition of the squalene-2,3-epoxidase enzyme, which in turn results in the shortage of ergosterol required for the formation of fungal cell membranes. With some fungal species, there is also fungicidal activity from a resulting accumulation of squalenes, leading to damage of the fungal cell membranes, including at the endoplasmatic reticulum.[1][2][3] Naftifine shows mostly fungicidal activity toward dermatophytes and molds, and mostly fungistatic activity toward yeasts. It is also effective as an antibacterial agent in treating pyoderma. [citation needed]
Naftifine is almost completely metabolized in the human body, with a half-life of 2–3 days.[3] The metabolites do not have antifungal activity, and are excreted within urine and feces.[4]
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