NRK (gene)

Nik-related protein kinase is an enzyme that, in humans, is encoded by the NRK gene.^[5]

NRK
Identifiers
Aliases	NRK, NESK, Nik related kinase
External IDs	OMIM: 300791; MGI: 1351326; HomoloGene: 8442; GeneCards: NRK; OMA:NRK - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.3 Start 105,822,539 bp[1] End 105,958,610 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F1|X 61.15 cM Start 137,815,179 bp[2] End 137,911,281 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia placenta cartilage tissue ovary left ovary tail of epididymis gonad parietal pleura germinal epithelium testicle Top expressed in human fetus internal carotid artery dermis atrium umbilical cord atrioventricular valve external carotid artery yolk sac abdominal wall endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity ATP binding kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase kinase activity Cellular component cytoplasm Biological process protein phosphorylation regulation of spongiotrophoblast cell proliferation birth phosphorylation negative regulation of cell population proliferation regulation of mitotic cell cycle stress-activated protein kinase signaling cascade regulation of apoptotic process neuron projection morphogenesis MAPK cascade signal transduction actin cytoskeleton reorganization activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 203447 27206 Ensembl ENSG00000123572 ENSMUSG00000052854 UniProt Q7Z2Y5 Q9R0G8 RefSeq (mRNA) NM_198465 NM_013724 RefSeq (protein) NP_940867 NP_038752 Location (UCSC) Chr X: 105.82 – 105.96 Mb Chr X: 137.82 – 137.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000123572 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052854 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NRK Nik related kinase".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakano K, Kanai-Azuma M, Kanai Y, et al. (2003). "Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family". Exp. Cell Res. 287 (2): 219–27. doi:10.1016/S0014-4827(03)00136-8. PMID 12837278.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.