NOX5

NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene.^[3][4]

NOX5
Identifiers
Aliases	NOX5, NADPH oxidase 5
External IDs	OMIM: 606572; HomoloGene: 41568; GeneCards: NOX5; OMA:NOX5 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 68,930,525 bp[1] End 69,062,762 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte thymus spleen secondary oocyte muscle tissue testicle right testis left testis metanephros placenta n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding proton channel activity calcium ion binding heme binding oxidoreductase activity flavin adenine dinucleotide binding NADP binding protein binding superoxide-generating NAD(P)H oxidase activity Cellular component integral component of membrane membrane endoplasmic reticulum endoplasmic reticulum membrane plasma membrane NADPH oxidase complex Biological process angiogenesis superoxide anion generation positive regulation of reactive oxygen species metabolic process regulation of fusion of sperm to egg plasma membrane apoptotic process ion transport regulation of proton transport cell population proliferation endothelial cell proliferation cellular response to oxidative stress proton transmembrane transport cytoskeleton-dependent cytokinesis defense response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79400 n/a Ensembl ENSG00000255346 n/a UniProt Q96PH1 n/a RefSeq (mRNA) NM_001184779 NM_001184780 NM_024505 n/a RefSeq (protein) NP_001171708 NP_001171709 NP_078781 n/a Location (UCSC) Chr 15: 68.93 – 69.06 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

NOX5 is a novel NADPH oxidase that generates superoxide.^[3]

Nox5 interacts with c-abl, superoxide production leads to phosphorylation of c-abl, while inhibition of c-abl kinase activity inhibits Nox5 superoxide production.^[5]