NKIRAS2

NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene.^[5]

NKIRAS2
Identifiers
Aliases	NKIRAS2, KBRAS2, kappaB-Ras2, NFKB inhibitor interacting Ras like 2
External IDs	OMIM: 604497; MGI: 1919216; HomoloGene: 9738; GeneCards: NKIRAS2; OMA:NKIRAS2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,011,382 bp[1] End 42,025,644 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 100,510,070 bp[2] End 100,518,433 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte ganglionic eminence stromal cell of endometrium gastrocnemius muscle left ventricle apex of heart muscle of thigh granulocyte right auricle popliteal artery Top expressed in spermatocyte spermatid seminiferous tubule granulocyte lip medial ganglionic eminence right ventricle neural tube cornea esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component cytoplasm membrane cellular component Biological process I-kappaB kinase/NF-kappaB signaling signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28511 71966 Ensembl ENSG00000168256 ENSMUSG00000017837 UniProt Q9NYR9 Q9CR56 RefSeq (mRNA) NM_001001349 NM_001144927 NM_001144928 NM_001144929 NM_017595 NM_028024 RefSeq (protein) NP_001001349 NP_001138399 NP_001138400 NP_001138401 NP_060065 NP_001001349.1 NP_001138399.1 NP_060065.2 NP_082300 Location (UCSC) Chr 17: 42.01 – 42.03 Mb Chr 11: 100.51 – 100.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000168256 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017837 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30.

Further reading

• Tago K, Funakoshi-Tago M, Sakinawa M, Mizuno N, Itoh H (Oct 2010). "KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA". The Journal of Biological Chemistry. 285 (40): 30622–33. doi:10.1074/jbc.M110.117028. PMC 2945557. PMID 20639196.
• Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee JW, Ghosh S (Feb 2000). "A subclass of Ras proteins that regulate the degradation of IkappaB". Science. 287 (5454): 869–73. Bibcode:2000Sci...287..869F. doi:10.1126/science.287.5454.869. PMID 10657303.
• Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario JL, Velloso ML, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna AR, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar MD, Blanco FJ, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino JJ, Gonzalez A (Apr 2009). "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis". Annals of the Rheumatic Diseases. 68 (4): 579–83. doi:10.1136/ard.2007.087304. PMID 18434448. S2CID 24874869.