NIPA2

Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 is a protein that in humans is encoded by the NIPA2 gene.^[5][6]

NIPA2
Identifiers
Aliases	NIPA2, non imprinted in Prader-Willi/Angelman syndrome 2, SLC57A2, NIPA magnesium transporter 2
External IDs	OMIM: 608146; MGI: 1913918; HomoloGene: 11368; GeneCards: NIPA2; OMA:NIPA2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q11.2 Start 22,838,644 bp[1] End 22,869,362 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B5 Start 55,581,035 bp[2] End 55,612,224 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of colon mucosa of sigmoid colon secondary oocyte mucosa of ileum nasal epithelium rectum right ventricle islet of Langerhans duodenum Top expressed in epithelium of small intestine submandibular gland gastrula ileum left colon transitional epithelium of urinary bladder interventricular septum atrioventricular valve jejunum epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function magnesium ion transmembrane transporter activity Cellular component integral component of membrane endosome plasma membrane early endosome membrane Biological process magnesium ion transmembrane transport ion transport magnesium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81614 93790 Ensembl ENSG00000140157 ENSMUSG00000030452 UniProt Q8N8Q9 Q9JJC8 RefSeq (mRNA) NM_001008860 NM_001008892 NM_001008894 NM_001184888 NM_001184889 NM_030922 NM_001256130 NM_001256131 NM_001256132 NM_001256133 NM_023647 RefSeq (protein) NP_001008860 NP_001008892 NP_001008894 NP_001171817 NP_001171818 NP_112184 NP_001243059 NP_001243060 NP_001243061 NP_001243062 NP_076136 Location (UCSC) Chr 15: 22.84 – 22.87 Mb Chr 7: 55.58 – 55.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000140157 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030452 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chai JH, Locke DP, Greally JM, Knoll JH, Ohta T, Dunai J, Yavor A, Eichler EE, Nicholls RD (Sep 2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons". Am J Hum Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708.
6. "Entrez Gene: NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2".

Further reading

• Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome". Pediatrics. 118 (4): e1276–e1283. doi:10.1542/peds.2006-0424. PMC 5453799. PMID 16982806.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lefèvre C, Bouadjar B, Karaduman A, et al. (2005). "Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis". Hum. Mol. Genet. 13 (20): 2473–2482. doi:10.1093/hmg/ddh263. PMID 15317751.
• Glinsky GV, Glinskii AB, Stephenson AJ, et al. (2004). "Gene expression profiling predicts clinical outcome of prostate cancer". J. Clin. Invest. 113 (6): 913–923. doi:10.1172/JCI20032. PMC 362118. PMID 15067324.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.