NFKB1

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.^[5]

NFKB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MDI, 1MDJ, 1MDK, 1NFI, 1SVC, 2DBF, 2O61, 3GUT
Identifiers
Aliases	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, CVID12, nuclear factor kappa B subunit 1, NF-kappa-B1, NF-kB, NF-kappabeta
External IDs	OMIM: 164011; MGI: 97312; HomoloGene: 2971; GeneCards: NFKB1; OMA:NFKB1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 102,501,331 bp[1] End 102,617,302 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 62.82 cM Start 135,290,416 bp[2] End 135,397,308 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue Achilles tendon monocyte appendix epithelium of colon gallbladder bone marrow cells rectum middle frontal gyrus blood Top expressed in granulocyte spleen thymus lactiferous gland lymph node lip otic vesicle Ileal epithelium right lung gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity chromatin binding protein binding DNA binding sequence-specific DNA binding actinin binding identical protein binding transcription cis-regulatory region binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm mitochondrion nucleus I-kappaB/NF-kappaB complex nucleoplasm extracellular region cytosol secretory granule lumen specific granule lumen Biological process cellular response to interleukin-6 positive regulation of canonical Wnt signaling pathway regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of vitamin D biosynthetic process Fc-epsilon receptor signaling pathway cellular response to mechanical stimulus NIK/NF-kappaB signaling stress-activated MAPK cascade negative regulation of inflammatory response apoptotic process response to muscle stretch regulation of transcription, DNA-templated stimulatory C-type lectin receptor signaling pathway transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of calcidiol 1-monooxygenase activity positive regulation of hyaluronan biosynthetic process membrane protein intracellular domain proteolysis inflammatory response I-kappaB kinase/NF-kappaB signaling positive regulation of miRNA metabolic process cellular response to nicotine negative regulation of transcription by RNA polymerase II positive regulation of macrophage derived foam cell differentiation positive regulation of NF-kappaB transcription factor activity negative regulation of cholesterol transport negative regulation of transcription, DNA-templated negative regulation of cytokine production positive regulation of lipid storage cellular response to dsRNA T cell receptor signaling pathway positive regulation of type I interferon production positive regulation of transcription by RNA polymerase II signal transduction cellular response to lipopolysaccharide cellular response to interleukin-1 innate immune response negative regulation of apoptotic process negative regulation of gene expression neutrophil degranulation cellular response to tumor necrosis factor cellular response to angiotensin interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4790 18033 Ensembl ENSG00000109320 ENSMUSG00000028163 UniProt P19838 P25799 RefSeq (mRNA) NM_001165412 NM_003998 NM_001319226 NM_001382625 NM_001382626 NM_001382627 NM_001382628 NM_008689 RefSeq (protein) NP_001158884 NP_001306155 NP_003989 NP_001369554 NP_001369555 NP_001369556 NP_001369557 NP_001158884.1 NP_001306155.1 NP_032715 Location (UCSC) Chr 4: 102.5 – 102.62 Mb Chr 3: 135.29 – 135.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.^[6]

Interactions

NFKB1 has been shown to interact with:

• BCL3,^[7][8][9]
• C22orf25,
• HDAC1,^[10]
• HMGA2^[11]
• IKK2,^[7][12]
• ITGB3BP,^[13]
• IκBα,^[14][15]
• LYL1,^[16]
• MAP3K7IP2,^[17]
• MAP3K8,^[18][19]
• MEN1,^[20]
• NFKB2,^[18]
• NFKBIE,^[21]
• NOTCH1,^[22][23]
• Nuclear receptor coactivator 1,^[24][25]
• RELA,^[18][26]
• RELB,^[18]
• STAT3,^[27]
• STAT6,^[28] and
• TSC22D3.^[29]