NFIC (gene)

Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene.^[5][6][7]

NFIC
Identifiers
Aliases	NFIC, CTF, CTF5, NF-I, NFI, nuclear factor I C
External IDs	OMIM: 600729; MGI: 109591; HomoloGene: 4088; GeneCards: NFIC; OMA:NFIC - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,314,403 bp[1] End 3,469,217 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,232,020 bp[2] End 81,291,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple parotid gland cardia pylorus seminal vesicula renal medulla pericardium urethra trigeminal ganglion body of tongue Top expressed in ankle lacrimal gland triceps brachii muscle aortic valve extensor digitorum longus muscle muscle of thigh ascending aorta plantaris muscle vestibular membrane of cochlear duct internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific double-stranded DNA binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus fibrillar center Biological process odontogenesis of dentin-containing tooth DNA replication negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4782 18029 Ensembl ENSG00000141905 ENSMUSG00000055053 UniProt P08651 P70255 RefSeq (mRNA) NM_001245002 NM_001245004 NM_001245005 NM_005597 NM_205843 NM_008688 NM_026756 RefSeq (protein) NP_001231931 NP_001231933 NP_001231934 NP_005588 NP_995315 NP_032714 NP_081032 Location (UCSC) Chr 19: 3.31 – 3.47 Mb Chr 10: 81.23 – 81.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000141905 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055053 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs". Nature. 334 (6179): 218–24. Bibcode:1988Natur.334..218S. doi:10.1038/334218a0. PMID 3398920. S2CID 4287831.
6. Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
7. "Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)".

Further reading

• Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC 231191. PMID 8628270.
• Wenzelides S, Altmann H, Wendler W, Winnacker EL (1996). "CTF5--a new transcriptional activator of the NFI/CTF family". Nucleic Acids Res. 24 (12): 2416–21. doi:10.1093/nar/24.12.2416. PMC 145930. PMID 8710515.
• Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
• Nogues G, Kadener S, Cramer P, et al. (2003). "Transcriptional activators differ in their abilities to control alternative splicing". J. Biol. Chem. 277 (45): 43110–4. doi:10.1074/jbc.M208418200. PMID 12221105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
• Wickenheisser JK, Nelson-DeGrave VL, Quinn PG, McAllister JM (2004). "Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1". Mol. Endocrinol. 18 (3): 588–605. doi:10.1210/me.2003-0090. PMID 14684846.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhao LH, Ba XQ, Wang XG, et al. (2005). "BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation". Acta Biochim. Biophys. Sin. (Shanghai). 37 (7): 440–6. doi:10.1111/j.1745-7270.2005.00061.x. PMID 15999204.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Nilsson J, Bjursell G, Kannius-Janson M (2006). "Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells". Mol. Cell. Biol. 26 (15): 5663–74. doi:10.1128/MCB.02095-05. PMC 1592781. PMID 16847321.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Hebbar PB, Archer TK (2007). "Chromatin-dependent cooperativity between site-specific transcription factors in vivo". J. Biol. Chem. 282 (11): 8284–91. doi:10.1074/jbc.M610554200. PMC 2528297. PMID 17186943.

External links

• NFIC+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.