NCAPG

Condensin complex subunit 3 also known as condensin subunit CAP-G (CAP-G) or non-SMC condensin I complex subunit G (NCAPG) is a protein that in humans is encoded by the NCAPG gene.^[5][6][7] CAP-G is a subunit of condensin I, a large protein complex involved in chromosome condensation.

NCAPG
Identifiers
Aliases	NCAPG, CAPG, CHCG, NY-MEL-3, YCG1, non-SMC condensin I complex subunit G
External IDs	OMIM: 606280; MGI: 1930197; HomoloGene: 44071; GeneCards: NCAPG; OMA:NCAPG - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.31 Start 17,810,979 bp[1] End 17,844,865 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 45,827,261 bp[2] End 45,857,888 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo ganglionic eminence gonad trabecular bone sperm bone marrow gingival epithelium testicle amniotic fluid Top expressed in otic placode secondary oocyte otic vesicle primary oocyte zygote saccule spermatocyte epiblast spermatid tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component condensin complex cytosol membrane condensed chromosome nucleus chromosome condensed chromosome, centromeric region cytoplasm Biological process cell division cell cycle mitotic chromosome condensation chromosome condensation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64151 54392 Ensembl ENSG00000109805 ENSMUSG00000015880 UniProt Q9BPX3 E9PWG6 RefSeq (mRNA) NM_022346 NM_019438 RefSeq (protein) NP_071741 NP_062311 Location (UCSC) Chr 4: 17.81 – 17.84 Mb Chr 5: 45.83 – 45.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NCAPG has been shown to interact with DNMT3B.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000109805 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015880 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jäger D, Stockert E, Jäger E, Güre AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
6. Kimura K, Cuvier O, Hirano T (Feb 2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
7. "Entrez Gene: NCAPG non-SMC condensin I complex, subunit G".
8. Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

Further reading

• Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
• Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge OK, Sarge KD (2005). "Mechanism of hsp70i gene bookmarking". Science. 307 (5708): 421–3. Bibcode:2005Sci...307..421X. doi:10.1126/science.1106478. PMID 15662014. S2CID 37132180.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.