N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.244, beta1,4-N-acetylgalactosaminyltransferase III, beta4GalNAc-T3, beta1,4-N-acetylgalactosaminyltransferase IV, beta4GalNAc-T4, UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group ${\displaystyle \rightleftharpoons }$ UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase
Identifiers
EC no.	2.4.1.244
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc).

References

1. Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H (November 2003). "Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc". The Journal of Biological Chemistry. 278 (48): 47534–44. doi:10.1074/jbc.m308857200. PMID 12966086.
2. Gotoh M, Sato T, Kiyohara K, Kameyama A, Kikuchi N, Kwon YD, Ishizuka Y, Iwai T, Nakanishi H, Narimatsu H (March 2004). "Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine". FEBS Letters. 562 (1–3): 134–40. doi:10.1016/s0014-5793(04)00219-4. PMID 15044014.

External links

• N-acetyl-beta-glucosaminyl-glycoprotein+4-beta-N-acetylgalactosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)