Myogenin

Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia

Myogenin

Myogenin, is a transcriptional activator encoded by the MYOG gene.[5] Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4.

Quick Facts MYOG, Identifiers ...
MYOG
Identifiers
AliasesMYOG, MYF4, bHLHc3, myf-4, myogenin (myogenic factor 4), myogenin
External IDsOMIM: 159980; MGI: 97276; HomoloGene: 1854; GeneCards: MYOG; OMA:MYOG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002479

NM_031189

RefSeq (protein)

NP_002470

NP_112466

Location (UCSC)Chr 1: 203.08 – 203.09 MbChr 1: 134.22 – 134.22 Mb
PubMed search[3][4]
Wikidata
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In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.[6][7]

In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.

Interactions

Myogenin has been shown to interact with:

References

Further reading

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