Mucin 5AC

Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans.^[5][6][7]

MUC5AC
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 5AJN, 5AJP, 5AJO
Identifiers
Aliases	MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs	OMIM: 158373; MGI: 104697; HomoloGene: 137237; GeneCards: MUC5AC; OMA:MUC5AC - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 1,157,953 bp[1] End 1,201,138 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 87.23 cM Start 141,342,709 bp[2] End 141,372,968 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa gastric mucosa body of stomach fundus gallbladder canal of the cervix islet of Langerhans appendix urinary bladder muscle tissue Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach conjunctival fornix duodenum olfactory epithelium quadriceps femoris muscle esophagus cornea pancreas More reference expression data BioGPS n/a
Gene ontology Molecular function extracellular matrix structural constituent Cellular component cytoplasm Golgi lumen extracellular region extracellular exosome extracellular space plasma membrane mucus layer Biological process phosphatidylinositol-mediated signaling O-glycan processing stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4586 17833 Ensembl ENSG00000215182 ENSG00000283158 ENSMUSG00000037974 UniProt P98088 n/a RefSeq (mRNA) NM_017511 NM_001304359 NM_010844 RefSeq (protein) NP_001291288 n/a Location (UCSC) Chr 11: 1.16 – 1.2 Mb Chr 7: 141.34 – 141.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,^[8] and has also been associated with greater protection against influenza infection.^[9]

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).^[10]

References

1. ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037974 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. doi:10.1042/bj3050211. PMC 1136451. PMID 7826332.
6. van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
7. "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
8. Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231: 116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150.
9. Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC (2012-10-09). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. Bibcode:2012PNAS..10916528E. doi:10.1073/pnas.1206552109. ISSN 1091-6490. PMC 3478656. PMID 23012413.
10. Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. 25 (19). Basel, Switzerland: 4437. doi:10.3390/molecules25194437. PMC 7582261. PMID 32992527.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC