Mischivirus

Mischivirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Bats serve as natural hosts. There are five species in this genus.^[1][2]

Mischivirus
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Pisuviricota
Class:	Pisoniviricetes
Order:	Picornavirales
Family:	Picornaviridae
Subfamily:	Caphthovirinae
Genus:	Mischivirus

Taxonomy

The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species:^[2][3]

• Mischivirus acombewi; Mischivirus A1, also called Minopterus schreibersii picornavirus
• Mischivirus beminio; Mischivirus B1, also called Bat picornavirus
• Mischivirus cica; Mischivirus C1, also called African bat icavirus
• Mischivirus defoxi; Mischivirus D1, also called Canine picornavirus
• Mischivirus ehoushre; Mischivirus E1, also called Suncus murinus mischivirus

Structure

Viruses in Mischivirus are non-enveloped, with icosahedral, spherical, and round geometries, and T=pseudo3 symmetry. The diameter is around 30 nm. Genomes are linear and non-segmented, around 8.5kb in length.^[1]

Genus	Structure	Symmetry	Capsid	Genomic arrangement	Genomic segmentation
Mischivirus	Icosahedral	Pseudo T=3	Non-enveloped	Linear	Monopartite

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the virus to host receptors, which mediates endocytosis. Replication follows the positive stranded RNA virus replication model. Positive stranded RNA virus transcription is the method of transcription. Translation takes place by ribosomal skipping. The virus exits the host cell by lysis, and viroporins. Bats serve as the natural host.^[1]

Genus	Host details	Tissue tropism	Entry details	Release details	Replication site	Assembly site	Transmission
Mischivirus	Bats	None	Cell receptor endocytosis	Lysis	Cytoplasm	Cytoplasm	Unknown