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From Wikipedia, the free encyclopedia
Michael Joseph Ezra Sternberg (born 24 June 1951)[1] is a professor at Imperial College London, where he is director of the Centre for Integrative Systems Biology and Bioinformatics[4] and Head of the Structural bioinformatics Group.[2][5][6][7]
Mike Sternberg | |
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Born | Michael Joseph Ezra Sternberg 24 June 1951[1] |
Alma mater |
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Awards | |
Scientific career | |
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Institutions | |
Thesis | Studies of Protein Conformation (1977) |
Doctoral advisor | David Chilton Phillips[3] |
Website | www |
Sternberg was educated at Hendon County Grammar School and Gonville and Caius College, Cambridge, where he was awarded a Bachelor of Arts degree in natural sciences (theoretical physics) in 1972.[1] He went on to do a Master of Science degree in Computing at Imperial College London followed by a DPhil degree from the University of Oxford (Wolfson College, Oxford) in 1978 for research supervised by David Chilton Phillips.[3][8][9][10][11][12]
After postdoctoral research at the University of Oxford, Sternberg became a Lecturer in the Department of Crystallography at Birkbeck College, London. He went on to work at the Imperial Cancer Research Fund and joined Imperial College in 2001.[1][13][14][15][16] He is the Director of the Centre for Integrative Systems Biology and Bioinformatics[4] at Imperial College.
Sternberg's research interests are in protein structure prediction, protein function prediction, prediction of macromolecular docking and interactions, network modelling for systems biology and logic-based drug design.[13][17][18][19][20][21][22][23][24][25]
He has authored or co-authored several books including From Cells to Atoms: an illustrated introduction to molecular biology,[26] Protein Engineering: a practical approach[27] and Protein Structure Prediction: a practical approach.[28]
During his DPhil research at Oxford he worked with Janet Thornton and they undertook some of the first systematic analyses of protein structure. They identified that the beta-alpha-beta unit in proteins is nearly always right handed and this explained remarkable similarities between protein structures.[citation needed]
His group, particularly Lawrence Kelley, have developed the widely used Phyre/Phyre2 web server[29][30][31] for protein structure prediction. This web resource has been used by over 100,000 distinct users worldwide.[citation needed]
Recently his PhD student Chris Yates developed SuSPect,[32] a novel powerful method to predict the phenotypic effects of Single-nucleotide polymorphisms and other amino acid variants.
Sternberg was elected a Fellow of the Royal Society of Biology (FRSB) and a Fellow of the Institute of Biology (FIBiol). He is an associate editor of the Journal of Molecular Biology.
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