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Chemical compound From Wikipedia, the free encyclopedia
Methylarsonic acid is an organoarsenic compound with the formula CH3AsO3H2. It is a colorless, water-soluble solid. Salts of this compound, e.g. disodium methyl arsonate, have been widely used in as herbicides and fungicides in growing cotton and rice.[2]
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Names | |
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Preferred IUPAC name
Methylarsonic acid[1] | |
Other names
Methanearsonic acid Monomethylarsonic acid | |
Identifiers | |
3D model (JSmol) |
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4-04-00-03682 | |
ChemSpider | |
ECHA InfoCard | 100.004.278 |
EC Number |
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PubChem CID |
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RTECS number |
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UNII | |
UN number | 1557 |
CompTox Dashboard (EPA) |
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Properties | |
CH5AsO3 | |
Molar mass | 139.970 g·mol−1 |
Appearance | white solid |
Melting point | 160.5 °C (320.9 °F; 433.6 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Near physiological pH, methanearsonic acid converts to its conjugate bases, the methylarsonates. These include CH3AsO3H− and CH
3AsO2−
3.
Reaction of arsenous acid with methyl iodide gives methylarsonic acid. This historically significant conversion is called the Meyer reaction:[3]
The then-novel aspect of the reaction was that alkylation occurs at arsenic, leading to oxidation of arsenic from oxidation state +3 to +5.
The biomethylation of arsenic compounds is thought to start with the formation of methanearsonates. Thus, trivalent arsenic compounds are methylated to give methanearsonate. S-Adenosylmethionine is the methyl donor. The methanearsonates are the precursors to cacodylates, again by the cycle of reduction (to methylarsonous acid) followed by a second methylation.[4]
Like most arsenic compounds, it is highly toxic.[4]
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