Melanoma antigen family a, 8

Melanoma antigen family A, 8 is a protein that in humans is encoded by the MAGEA8 gene. ^[3]

MAGEA8
Identifiers
Aliases	MAGEA8, CT1.8, MAGE8, Melanoma antigen family a, 8, MAGE family member A8
External IDs	OMIM: 300341; HomoloGene: 74553; GeneCards: MAGEA8; OMA:MAGEA8 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 149,881,141 bp[1] End 149,885,835 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta gonad right testis left testis gastric mucosa right hemisphere of cerebellum cervix body of uterus muscle of thigh canal of the cervix n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4107 n/a Ensembl ENSG00000156009 n/a UniProt P43361 n/a RefSeq (mRNA) NM_005364 NM_001166400 NM_001166401 n/a RefSeq (protein) NP_001159872 NP_001159873 NP_005355 n/a Location (UCSC) Chr X: 149.88 – 149.89 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References

1. GRCh38: Ensembl release 89: ENSG00000156009 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Melanoma antigen family A, 8". Retrieved 2014-08-25.

Further reading

• De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethé B, Lurquin C (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540. S2CID 11331427.
• Rogner UC, Wilke K, Steck E, Korn B, Poustka A (October 1995). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
• Serrano A, Lethé B, Delroisse JM, Lurquin C, De Plaen E, Brasseur F, Rimoldi D, Boon T (November 1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries". International Journal of Cancer. 83 (5): 664–9. doi:10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V. PMID 10521804.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.