Melanin-concentrating hormone receptor

"MCHR" redirects here. For the defunct healthcare advocacy group, see Medical Committee for Human Rights.

Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.

• MCH-R1 is expressed in all mammals.
• MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.

melanin-concentrating hormone receptor 1
Identifiers
Symbol	MCHR1
Alt. symbols	GPR24
NCBI gene	2847
HGNC	4479
OMIM	601751
RefSeq	NM_005297
UniProt	Q99705
Other data
Locus	Chr. 22 q13.3
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melanin-concentrating hormone receptor 2
Identifiers
Symbol	MCHR2
Alt. symbols	GPR145
NCBI gene	84539
HGNC	20867
OMIM	606111
RefSeq	NM_032503
UniProt	Q969V1
Other data
Locus	Chr. 6 q16
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Clinical significance

Antagonists might be useful in the treatment of obesity^[1][2] and anxiety and depression.^[3] An agonist might have possible utility as a treatment for osteoporosis^[4] and insomnia^[5]

Research is ongoing for antagonists affecting MCH receptors R1 and R2.^[6][7]

See also

• Melanin concentrating hormone
• Melanin