MYT1

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.^[5][6][7]

MYT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JX1, 2JYD, 2MF8
Identifiers
Aliases	MYT1, C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A, ZC2H2C1, myelin transcription factor 1
External IDs	OMIM: 600379; MGI: 1100535; HomoloGene: 3332; GeneCards: MYT1; OMA:MYT1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 64,102,394 bp[1] End 64,242,253 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 103.77 cM Start 181,763,332 bp[2] End 181,827,797 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Cerebellum cerebellar hemisphere right hemisphere of cerebellum Hypothalamus Amygdala substantia nigra nucleus accumbens testicle islet of Langerhans Top expressed in lumbar spinal ganglion Rostral migratory stream ganglionic eminence neural layer of retina ventricular zone medial ganglionic eminence zygote autonomic nervous system superior cervical ganglion trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity zinc ion binding metal ion binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process multicellular organism development nervous system development regulation of transcription, DNA-templated cell differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4661 17932 Ensembl ENSG00000196132 ENSMUSG00000010505 UniProt Q01538 Q8CFC2 RefSeq (mRNA) NM_004535 NM_001171615 NM_001171616 NM_001171680 NM_008665 RefSeq (protein) NP_004526 NP_001165086 NP_001165087 NP_001165151 NP_032691 Location (UCSC) Chr 20: 64.1 – 64.24 Mb Chr 2: 181.76 – 181.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to visit related articles. ^{[§ 1]}

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|alt=MECP2 and associated Rett Syndrome edit]]

MECP2 and associated Rett Syndrome edit

1. The interactive pathway map can be edited at WikiPathways: "WP3584".

Interactions

MYT1 has been shown to interact with PIN1.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000196132 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010505 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.
6. Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
7. "Entrez Gene: MYT1 myelin transcription factor 1".
8. Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science. 112 (19): 3361–71. doi:10.1242/jcs.112.19.3361. PMID 10504341.

Further reading

• Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M (August 1994). "Plasticity in the adult human oligodendrocyte lineage". The Journal of Neuroscience. 14 (8): 4571–87. doi:10.1523/JNEUROSCI.14-08-04571.1994. PMC 6577192. PMID 7519254.
• Armstrong RC, Kim JG, Hudson LD (August 1995). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia. 14 (4): 303–21. doi:10.1002/glia.440140407. PMID 8530187. S2CID 38779689.
• Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (February 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Molecular and Cellular Biology. 17 (2): 571–83. doi:10.1128/mcb.17.2.571. PMC 231782. PMID 9001210.
• Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD (October 1997). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system". Journal of Neuroscience Research. 50 (2): 272–90. doi:10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A. PMID 9373037. S2CID 37120295.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S (January 2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Research. Developmental Brain Research. 140 (1): 85–92. doi:10.1016/S0165-3806(02)00585-0. PMID 12524179.
• Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (January 2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Molecular and Cellular Neurosciences. 25 (1): 111–23. doi:10.1016/j.mcn.2003.10.001. PMID 14962745. S2CID 28151272.
• Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (May 2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS". Glia. 55 (7): 687–97. doi:10.1002/glia.20492. PMC 2789289. PMID 17330875.

External links

• MYT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.