MYT1

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.^[5][6][7]

MYT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JX1, 2JYD, 2MF8
Identifiers
Aliases	MYT1, C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A, ZC2H2C1, myelin transcription factor 1
External IDs	OMIM: 600379; MGI: 1100535; HomoloGene: 3332; GeneCards: MYT1; OMA:MYT1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 64,102,394 bp[1] End 64,242,253 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 103.77 cM Start 181,763,332 bp[2] End 181,827,797 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Cerebellum cerebellar hemisphere right hemisphere of cerebellum Hypothalamus Amygdala substantia nigra nucleus accumbens testicle islet of Langerhans Top expressed in lumbar spinal ganglion Rostral migratory stream ganglionic eminence neural layer of retina ventricular zone medial ganglionic eminence zygote autonomic nervous system superior cervical ganglion trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity zinc ion binding metal ion binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process multicellular organism development nervous system development regulation of transcription, DNA-templated cell differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4661 17932 Ensembl ENSG00000196132 ENSMUSG00000010505 UniProt Q01538 Q8CFC2 RefSeq (mRNA) NM_004535 NM_001171615 NM_001171616 NM_001171680 NM_008665 RefSeq (protein) NP_004526 NP_001165086 NP_001165087 NP_001165151 NP_032691 Location (UCSC) Chr 20: 64.1 – 64.24 Mb Chr 2: 181.76 – 181.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to visit related articles. ^{[§ 1]}

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|alt=MECP2 and associated Rett Syndrome edit]]

MECP2 and associated Rett Syndrome edit

1. The interactive pathway map can be edited at WikiPathways: "WP3584".

Interactions

MYT1 has been shown to interact with PIN1.^[8]