MT-RNR2

Mitochondrially encoded 16S RNA (often abbreviated as 16S) is the mitochondrial large subunit ribosomal RNA^[1][2] that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.^[3]

mitochondrially encoded 16S RNA
Identifiers
Symbol	MT-RNR2
Alt. symbols	MTRNR2
NCBI gene	4550
HGNC	7471
UniProt	Q8IVG9
Other data
Locus	Chr. MT
Search for Structures Swiss-model Domains InterPro

Location of the MT-RNR2 gene on the H strand of the human mitochondrial genome. MT-RNR2, or RRNL, is one of the two mitochondrial ribosomal RNA genes (blue boxes).

The 16S rRNA is the mitochondrial homologue of the prokaryotic 23S and eukaryotic nuclear 28S ribosomal RNAs.^[4]

See also

• Mitochondrial DNA
• Humanin

References

1. Noda R, Kim CG, Takenaka O, Ferrell RE, Tanoue T, Hayasaka I, et al. (2001). "Mitochondrial 16S rRNA sequence diversity of hominoids". The Journal of Heredity. 92 (6): 490–496. doi:10.1093/jhered/92.6.490. PMID 11948216.
2. Nagy A, Wilhelm M, Kovacs G (February 2003). "Mutations of mtDNA in renal cell tumours arising in end-stage renal disease". The Journal of Pathology. 199 (2): 237–242. doi:10.1002/path.1273. PMID 12533837. S2CID 35602546.
3. Tajima H, Niikura T, Hashimoto Y, Ito Y, Kita Y, Terashita K, et al. (May 2002). "Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults". Neuroscience Letters. 324 (3): 227–231. doi:10.1016/S0304-3940(02)00199-4. PMID 12009529. S2CID 12088367.
4. Eperon IC, Anderson S, Nierlich DP (July 1980). "Distinctive sequence of human mitochondrial ribosomal RNA genes". Nature. 286 (5772): 460–467. Bibcode:1980Natur.286..460E. doi:10.1038/286460a0. PMID 6157106. S2CID 4262269.