MST1R

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.^[5][6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.^[5][7]

MST1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PLS, 4FWW, 4QT8
Identifiers
Aliases	MST1R, CD136, CDw136, PTK8, RON, macrophage stimulating 1 receptor, NPCA3, SEA
External IDs	OMIM: 600168; MGI: 99614; HomoloGene: 1835; GeneCards: MST1R; OMA:MST1R - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,887,002 bp[1] End 49,903,873 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 59.07 cM|9 F1 Start 107,784,072 bp[2] End 107,797,582 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon skin of leg skin of abdomen rectum body of stomach mucosa of ileum gallbladder gastric mucosa upper lobe of left lung testicle Top expressed in lip epithelium of stomach duodenum intestinal villus Ileal epithelium large intestine colon jejunum mucous cell of stomach esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity macrophage colony-stimulating factor receptor activity kinase activity protein binding enzyme binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding Wnt-protein binding Cellular component integral component of membrane membrane integral component of plasma membrane stress fiber cell surface vacuole plasma membrane receptor complex Biological process defense response positive regulation of protein kinase B signaling positive regulation of MAP kinase activity phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway immune system process single fertilization protein phosphorylation positive regulation of cell population proliferation peptidyl-tyrosine phosphorylation innate immune response signal transduction macrophage colony-stimulating factor signaling pathway hepatocyte growth factor receptor signaling pathway response to virus Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4486 19882 Ensembl ENSG00000164078 ENSMUSG00000032584 UniProt Q04912 Q62190 RefSeq (mRNA) NM_001244937 NM_002447 NM_001318913 NM_001287261 NM_009074 RefSeq (protein) NP_001231866 NP_001305842 NP_002438 NP_001274190 NP_033100 Location (UCSC) Chr 3: 49.89 – 49.9 Mb Chr 9: 107.78 – 107.8 Mb PubMed search [3] [4]
Wikidata
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Interactions

MST1R has been shown to interact with Grb2.^[8][9]