MST1R

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.^[5][6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.^[5][7]

MST1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PLS, 4FWW, 4QT8
Identifiers
Aliases	MST1R, CD136, CDw136, PTK8, RON, macrophage stimulating 1 receptor, NPCA3, SEA
External IDs	OMIM: 600168; MGI: 99614; HomoloGene: 1835; GeneCards: MST1R; OMA:MST1R - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,887,002 bp[1] End 49,903,873 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 59.07 cM|9 F1 Start 107,784,072 bp[2] End 107,797,582 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon skin of leg skin of abdomen rectum body of stomach mucosa of ileum gallbladder gastric mucosa upper lobe of left lung testicle Top expressed in lip epithelium of stomach duodenum intestinal villus Ileal epithelium large intestine colon jejunum mucous cell of stomach esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity macrophage colony-stimulating factor receptor activity kinase activity protein binding enzyme binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding Wnt-protein binding Cellular component integral component of membrane membrane integral component of plasma membrane stress fiber cell surface vacuole plasma membrane receptor complex Biological process defense response positive regulation of protein kinase B signaling positive regulation of MAP kinase activity phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway immune system process single fertilization protein phosphorylation positive regulation of cell population proliferation peptidyl-tyrosine phosphorylation innate immune response signal transduction macrophage colony-stimulating factor signaling pathway hepatocyte growth factor receptor signaling pathway response to virus Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4486 19882 Ensembl ENSG00000164078 ENSMUSG00000032584 UniProt Q04912 Q62190 RefSeq (mRNA) NM_001244937 NM_002447 NM_001318913 NM_001287261 NM_009074 RefSeq (protein) NP_001231866 NP_001305842 NP_002438 NP_001274190 NP_033100 Location (UCSC) Chr 3: 49.89 – 49.9 Mb Chr 9: 107.78 – 107.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MST1R has been shown to interact with Grb2.^[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000164078 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032584 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195–202. PMID 8386824.
6. "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)".
7. Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. doi:10.1002/j.1460-2075.1994.tb06659.x. PMC 395256. PMID 8062829.
8. Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
9. Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. doi:10.1002/j.1460-2075.1996.tb00973.x. PMC 452340. PMID 8918464.

Further reading

• Li BQ, Wang MH, Kung HF, et al. (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
• Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science. 266 (5182): 117–9. Bibcode:1994Sci...266..117W. doi:10.1126/science.7939629. PMID 7939629.
• Gaudino G, Follenzi A, Naldini L, et al. (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. doi:10.1002/j.1460-2075.1994.tb06659.x. PMC 395256. PMID 8062829.
• Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.
• Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype". Mol. Cell. Biol. 16 (10): 5518–26. doi:10.1128/MCB.16.10.5518. PMC 231551. PMID 8816464.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Iwama A, Yamaguchi N, Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. doi:10.1002/j.1460-2075.1996.tb00973.x. PMC 452340. PMID 8918464.
• Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 (4): 701–9. doi:10.1172/JCI119214. PMC 507853. PMID 9045873.
• Follenzi A, Bakovic S, Gual P, et al. (2000). "Cross-talk between the proto-oncogenes Met and Ron". Oncogene. 19 (27): 3041–9. doi:10.1038/sj.onc.1203620. PMID 10871856.
• Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo". Oncogene. 21 (41): 6382–6. doi:10.1038/sj.onc.1205783. PMID 12214279.
• Chen YQ, Zhou YQ, Fu LH, et al. (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais". Carcinogenesis. 23 (11): 1811–9. doi:10.1093/carcin/23.11.1811. PMID 12419829.
• Zhou YQ, He C, Chen YQ, et al. (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential". Oncogene. 22 (2): 186–97. doi:10.1038/sj.onc.1206075. PMID 12527888.
• Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580–5. Bibcode:2003PNAS..100.4580D. doi:10.1073/pnas.0837136100. PMC 153598. PMID 12676986.
• Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol. 27 (6): 779–85. doi:10.1097/00000478-200306000-00008. PMID 12766581. S2CID 21112098.
• Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor". Oncogene. 22 (24): 3669–79. doi:10.1038/sj.onc.1206585. PMID 12802274.
• Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res. 288 (2): 382–9. doi:10.1016/S0014-4827(03)00250-7. PMID 12915129.
• Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell. 5 (2): 257–71. doi:10.1016/S1534-5807(03)00201-6. PMID 12919677.
• Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
• van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors". Blood. 103 (12): 4457–65. doi:10.1182/blood-2003-08-2713. PMID 14982882. S2CID 8097946.
• Raeppel S, Gaudette G, et al. (2010). "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors". Bioorg. Med. Chem. Lett. 20 (9): 2745–9. doi:10.1016/j.bmcl.2010.03.073. PMID 20363625.