Loading AI tools
From Wikipedia, the free encyclopedia
MOPP is a combination chemotherapy regimen used to treat Hodgkin lymphoma. The acronym is derived from the component drugs of the regimen:
This article needs more reliable medical references for verification or relies too heavily on primary sources. (November 2021) |
The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin lymphoma treatment is ABVD.
C-MOPP involves switching the nitrogen mustard from mechlorethamine to cyclophosphamide. C-MOPP is thus very similar to COPP, using the same 4 agents and differing at most in dosages and timing.
Drug | Dose | Mode | Days |
---|---|---|---|
(M)ustargen | 6 mg/m2 | IV bolus | Days 1 and 8 |
(O)ncovin | 1.4 mg/m2 (max. 2 mg) | IV bolus | Days 1 and 8 |
(P)rocarbazine | 100 mg/m2 | PO qd | Days 1-14 |
(P)rednisone | 40 mg/m2 | PO qd | Days 1-14 |
MOPP was the first combination chemotherapy brought in that achieved a high success rate. It was developed at the National Cancer Institute in the 1960s by a team that included Vincent DeVita, Jr.
Although no longer the most effective combination, MOPP is still used after relapse or where the patient has certain allergies or lung or heart problems which prevents the use of another regimen.
There is 20% chance of developing a second cancer within 20 years of MOPP treatment. As a result, MOPP is rarely used any more for treatment for Hodgkin lymphoma.[1] MOPP has been known to cause alopecia (hair loss) and skin sensitivity (especially to sunlight). Nausea, vomiting, and stomach ache are common, as are chills, constipation, and frequent urination. Permanent sterility is a frequent side effect.
Seamless Wikipedia browsing. On steroids.
Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.
Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.