MGS-0039

MGS-0039
Clinical data
ATC code	None;
Legal status
Legal status	In general: non-regulated;
Identifiers
	IUPAC name (1R,2R,3R,5R,6R)-2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid;
CAS Number	569686-87-9;
PubChem CID	9886034;
IUPHAR/BPS	1397;
ChemSpider	8061707;
UNII	M8KC1PQ31A;
CompTox Dashboard (EPA)	DTXSID40432407 ;
Chemical and physical data
Formula	C15H14Cl2NO5
Molar mass	359.18 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES F[C@@]2(C(=O)O)[C@H]3[C@@](C(=O)O)(N)[C@H](OCc1ccc(Cl)c(Cl)c1)C[C@@H]23;
	InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1; Key:LFAGGDAZZKUVKO-JAGWWQSPSA-N;

MGS-0039 is a drug that is used in neuroscientific research, which acts as a potent and selective antagonist for group II of the metabotropic glutamate receptors (mGluR_2/3).^[1]^[2] It produces antidepressant and anxiolytic effects in animal studies,^[3]^[4]^[5]^[6] and has been shown to boost release of dopamine and serotonin in specific brain areas.^[7]^[8] Research has suggested this may occur through a similar mechanism as that suggested for the similarly glutamatergic drug ketamine.^[9]^[10]

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