MEX3D

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.^[5][6]

MEX3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DGR
Identifiers
Aliases	MEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDs	OMIM: 611009; MGI: 2681847; HomoloGene: 16890; GeneCards: MEX3D; OMA:MEX3D - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,554,672 bp[1] End 1,568,325 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,216,189 bp[2] End 80,223,493 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis ganglionic eminence ventricular zone secondary oocyte stromal cell of endometrium C1 segment mucosa of transverse colon sural nerve left ovary Top expressed in seminiferous tubule hand medial ganglionic eminence mandibular prominence maxillary prominence superior cervical ganglion spermatid endocardial cushion Gonadal ridge Rostral migratory stream More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding nucleic acid binding RNA binding mRNA 3'-UTR AU-rich region binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus Biological process mRNA destabilization mRNA localization resulting in posttranscriptional regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 399664 237400 Ensembl ENSG00000181588 ENSMUSG00000048696 UniProt Q86XN8 Q3UE17 RefSeq (mRNA) NM_001174118 NM_203304 NM_198615 RefSeq (protein) NP_001167589 NP_976049 NP_941017 Location (UCSC) Chr 19: 1.55 – 1.57 Mb Chr 10: 80.22 – 80.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.^[6]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000181588 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048696 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: mex-3 homolog D (C. elegans)".
6. Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.