MDPHP

MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s,^[1] which has been reported as a novel designer drug. In the UK its slang name is monkey dust.^[2][3] It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV.^[4][5][6][7]

MDPHP

Legal status
Legal status	CA: Schedule I DE: NpSG (Industrial and scientific use only) UK: Class B Illegal in Japan and Hungary
Identifiers
IUPAC name 1-(2H-1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one
CAS Number	776994-64-0
PubChem CID	119057580
ChemSpider	52085733
UNII	7P3X2C24CS
CompTox Dashboard (EPA)	DTXSID701018396
Chemical and physical data
Formula	C17H23NO3
Molar mass	289.375 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCC(C(=O)C1=CC2=C(C=C1)OCO2)N3CCCC3
InChI InChI=1S/C17H23NO3/c1-2-3-6-14(18-9-4-5-10-18)17(19)13-7-8-15-16(11-13)21-12-20-15/h7-8,11,14H,2-6,9-10,12H2,1H3 Key:OBLFRFGUZZRECT-UHFFFAOYSA-N

Pharmacology

MDPHP powder

MDPHP acts as a potent norepinephrine-dopamine reuptake inhibitor. The IC50 values for MDPHP are 0.06 μM at NET, 0.05 μM at DAT and 9 μM at SERT.^[8]

Legal status

MDPHP is specifically listed as a controlled substance in Japan ^[9] and Hungary,^[10] and is controlled under analogue provisions in a number of other jurisdictions.

Documented fatalities

A case of a "fatal acute intoxication caused by MDPHP" in a 48 year old male was reported in February 2022 by physicians at an Italian hospital.^[11] Another case has been reported, involving a 30-years-old male cocaine consumer, found dead on July 20th, 2023, in Florence, Italy.^[12]

See also

• α-Pyrrolidinohexiophenone (α-PHP)
• 3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP)
• 3F-PHP
• 4F-PHP
• 4-Cl-PHP
• 5-BPDi
• N-Ethylhexedrone
• N-Ethylhexylone
• MDPEP