MCT-1

MCTS1, re-initiation and release factor, otherwise known as MCT-1, is a protein that in humans is encoded by the MCTS1 gene. ^[5]

MCTS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3R90
Identifiers
Aliases	MCTS1, MCT-1, MCT1, malignant T-cell amplified sequence 1, re-initiation and release factor, MCTS1 re-initiation and release factor
External IDs	OMIM: 300587; MGI: 1916245; HomoloGene: 5803; GeneCards: MCTS1; OMA:MCTS1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 120,594,010 bp[1] End 120,621,159 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A3.3 Start 37,689,455 bp[2] End 37,702,303 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon islet of Langerhans body of pancreas prefrontal cortex ganglionic eminence stromal cell of endometrium pituitary gland anterior pituitary tonsil right adrenal gland Top expressed in facial motor nucleus barrel cortex superior cervical ganglion anterior horn of spinal cord medial ganglionic eminence sternocleidomastoid muscle soleus muscle dermis endothelial cell of lymphatic vessel triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function translation initiation factor activity RNA binding protein binding Cellular component plasma membrane cytosolic small ribosomal subunit cytoplasm cytosol Biological process translational initiation cell cycle regulation of growth regulation of transcription, DNA-templated ribosome disassembly protein biosynthesis formation of translation preinitiation complex transcription, DNA-templated positive regulation of cell population proliferation cellular response to DNA damage stimulus translation reinitiation IRES-dependent viral translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28985 68995 Ensembl ENSG00000232119 ENSG00000288295 ENSMUSG00000000355 UniProt Q9ULC4 Q9DB27 RefSeq (mRNA) NM_001137554 NM_014060 NM_026902 NM_001356359 NM_001356360 NM_001361381 NM_001361382 RefSeq (protein) NP_001131026 NP_054779 NP_081178 NP_001343288 NP_001343289 NP_001348310 NP_001348311 Location (UCSC) Chr X: 120.59 – 120.62 Mb Chr X: 37.69 – 37.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Eukaryotic translation
• Eukaryotic initiation factor

References

1. ENSG00000288295 GRCh38: Ensembl release 89: ENSG00000232119, ENSG00000288295 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000355 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MCTS1, re-initiation and release factor". Retrieved 2018-01-01.

Further reading

• Shi B, Hsu HL, Evens AM, Gordon LI, Gartenhaus RB (2003). "Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies". Blood. 102 (1): 297–302. doi:10.1182/blood-2002-11-3486. PMID 12637315.
• Shi B, Levenson V, Gartenhaus RB (2003). "Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter". J. Cell. Biochem. 90 (1): 68–79. doi:10.1002/jcb.10609. PMID 12938157. S2CID 31678534.
• Mazan-Mamczarz K, Hagner P, Dai B, Corl S, Liu Z, Gartenhaus RB (2009). "Targeted suppression of MCT-1 attenuates the malignant phenotype through a translational mechanism". Leuk. Res. 33 (3): 474–82. doi:10.1016/j.leukres.2008.08.012. PMID 18824261.
• Kasiappan R, Shih HJ, Chu KL, Chen WT, Liu HP, Huang SF, Choy CO, Shu CL, Din R, Chu JS, Hsu HL (2009). "Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity". Mol. Cancer Res. 7 (4): 536–48. doi:10.1158/1541-7786.MCR-08-0422. PMID 19372582.
• Pérez-Arellano I, Gozalbo-Rovira R, Martínez AI, Cervera J (2010). "Expression and purification of recombinant human MCT-1 oncogene in insect cells". Protein J. 29 (2): 69–74. doi:10.1007/s10930-009-9223-y. PMID 20076993. S2CID 5299658.
• Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y (2010). "Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression". Clin. Exp. Metastasis. 27 (8): 557–69. doi:10.1007/s10585-010-9345-9. PMID 20658178. S2CID 26525740.
• Narumi K, Furugen A, Kobayashi M, Otake S, Itagaki S, Iseki K (2010). "Regulation of monocarboxylate transporter 1 in skeletal muscle cells by intracellular signaling pathways". Biol. Pharm. Bull. 33 (9): 1568–73. doi:10.1248/bpb.33.1568. PMID 20823576.
• Kasiappan R, Shih HJ, Wu MH, Choy C, Lin TD, Chen L, Hsu HL (2010). "The antagonism between MCT-1 and p53 affects the tumorigenic outcomes". Mol. Cancer. 9: 311. doi:10.1186/1476-4598-9-311. PMC 3019166. PMID 21138557.
• Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL (2012). "The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities". Cell Cycle. 11 (5): 934–52. doi:10.4161/cc.11.5.19452. PMID 22336915.