MASP2 (protein)

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene.^[5][6][7]

MASP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FXG, 1Q3X, 1SZB, 1ZJK, 3TVJ
Identifiers
Aliases	MASP2, MAP19, MASP-2, MASP1P1, sMAP, mannan binding lectin serine peptidase 2, Mannan-binding lectin serine protease 2, MBL associated serine protease 2, MAP-2
External IDs	OMIM: 605102; MGI: 1330832; HomoloGene: 4819; GeneCards: MASP2; OMA:MASP2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,026,523 bp[1] End 11,047,239 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 148,687,011 bp[2] End 148,699,956 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver cerebellar hemisphere right hemisphere of cerebellum pancreatic ductal cell left uterine tube monocyte muscle of leg gastrocnemius muscle skin of leg tibial nerve Top expressed in left lobe of liver gallbladder superior surface of tongue morula superior frontal gyrus primary visual cortex muscle of thigh ascending aorta embryo lumbar spinal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding peptidase activity serine-type peptidase activity protein binding hydrolase activity calcium-dependent protein binding metal ion binding complement component C4b binding serine-type endopeptidase activity Cellular component extracellular region extracellular exosome extracellular space Biological process complement activation, lectin pathway proteolysis complement activation, classical pathway immune system process innate immune response complement activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10747 17175 Ensembl ENSG00000009724 ENSMUSG00000028979 UniProt O00187 Q91WP0 RefSeq (mRNA) NM_139208 NM_006610 NM_001003893 NM_010767 RefSeq (protein) NP_006601 NP_631947 NP_001003893 NP_034897 Location (UCSC) Chr 1: 11.03 – 11.05 Mb Chr 4: 148.69 – 148.7 Mb PubMed search [3] [4]
Wikidata
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Function

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.^{[5][citation needed]}

MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.

See also

• MASP1 (protein)
• Mannan-binding lectin
• Mannan-binding lectin pathway (lectin pathway)