MARK4

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.^[5][6][7] MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules.^[8] Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.^[9]

MARK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5ES1
Identifiers
Aliases	MARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D, microtubule affinity regulating kinase 4
External IDs	OMIM: 606495; MGI: 1920955; HomoloGene: 57146; GeneCards: MARK4; OMA:MARK4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,079,288 bp[1] End 45,305,284 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 19,158,700 bp[2] End 19,192,746 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus ganglionic eminence prefrontal cortex parotid gland Region I of hippocampus proper stromal cell of endometrium right testis left testis endothelial cell putamen Top expressed in internal carotid artery external carotid artery granulocyte lip motor neuron neural layer of retina superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity microtubule binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity ubiquitin binding protein binding gamma-tubulin binding ATP binding tau protein binding Cellular component ciliary basal body cytosol centrosome microtubule cytoskeleton neuron projection cytoskeleton cell projection cytoplasm microtubule organizing center gamma-tubulin complex dendrite midbody Biological process phosphorylation positive regulation of programmed cell death nervous system development protein phosphorylation microtubule bundle formation cell cycle cell division establishment of cell polarity microtubule cytoskeleton organization cell projection organization ciliary basal body-plasma membrane docking intracellular signal transduction cilium organization positive regulation of cilium assembly regulation of centrosome cycle positive regulation of protein localization to centrosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57787 232944 Ensembl ENSG00000007047 ENSMUSG00000030397 UniProt Q96L34 Q8CIP4 RefSeq (mRNA) NM_001199867 NM_031417 NM_172279 NM_001368427 RefSeq (protein) NP_001186796 NP_113605 NP_758483 NP_001355356 Location (UCSC) Chr 19: 45.08 – 45.31 Mb Chr 7: 19.16 – 19.19 Mb PubMed search [3] [4]
Wikidata
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There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau protein in this disease.

Interactions

MARK4 has been shown to interact with USP9X^[10] and Ubiquitin C.^[10]