MAP4

Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.^[5]

MAP4
Identifiers
Aliases	MAP4, microtubule associated protein 4
External IDs	OMIM: 157132; MGI: 97178; HomoloGene: 1780; GeneCards: MAP4; OMA:MAP4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 47,850,690 bp[1] End 48,089,272 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F2|9 59.83 cM Start 109,931,460 bp[2] End 110,083,955 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve internal globus pallidus inferior olivary nucleus endothelial cell optic nerve tendon of biceps brachii C1 segment inferior ganglion of vagus nerve ventral tegmental area subthalamic nucleus Top expressed in neural layer of retina blastocyst muscle of thigh dentate gyrus of hippocampal formation granule cell morula cerebellar cortex mammillary body dorsomedial hypothalamic nucleus superior frontal gyrus sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding structural molecule activity tubulin binding protein binding RNA binding Cellular component microtubule associated complex neuron projection axoneme mitotic spindle microtubule extracellular exosome cytoskeleton cytoplasm postsynaptic density cytosol plasma membrane microtubule cytoskeleton axon Biological process mitotic spindle organization microtubule sliding cell division negative regulation of non-motile cilium assembly establishment of spindle orientation neuron projection development microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4134 17758 Ensembl ENSG00000047849 ENSMUSG00000032479 UniProt P27816 P27546 RefSeq (mRNA) NM_001134364 NM_001134365 NM_002375 NM_030884 NM_030885 NM_001205330 NM_001205331 NM_001205332 NM_008633 NM_001311163 NM_001311164 RefSeq (protein) NP_001127836 NP_002366 NP_112147 NP_001192259 NP_001192260 NP_001192261 NP_001298092 NP_001298093 NP_032659 Location (UCSC) Chr 3: 47.85 – 48.09 Mb Chr 9: 109.93 – 110.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.^[6] uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.^[7] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.^[8] mMAP4 is a muscle-specific isoform.^[8][9]