MAGEA1

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.^[3]

MAGEA1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1W72, 3BO8
Identifiers
Aliases	MAGEA1, CT1.1, MAGE1, MAGE family member A1
External IDs	OMIM: 300016; HomoloGene: 88717; GeneCards: MAGEA1; OMA:MAGEA1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,179,284 bp[1] End 153,183,880 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right testis left testis urinary bladder human musculoskeletal system kidney muscular system muscle renal cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone deacetylase binding protein binding Cellular component cytoplasm plasma membrane nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4100 n/a Ensembl ENSG00000198681 n/a UniProt P43355 n/a RefSeq (mRNA) NM_004988 n/a RefSeq (protein) NP_004979 n/a Location (UCSC) Chr X: 153.18 – 153.18 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000198681 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7. doi:10.1126/science.1840703. PMID 1840703.
4. "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)".

Further reading

• Takahashi K, Shichijo S, Noguchi M, et al. (1995). "Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis". Cancer Res. 55 (16): 3478–82. PMID 7627949.
• Celis E, Fikes J, Wentworth P, et al. (1995). "Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles". Mol. Immunol. 31 (18): 1423–30. doi:10.1016/0161-5890(94)90158-9. PMID 7823968.
• De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540. S2CID 11331427.
• Schultz-Thater E, Juretic A, Dellabona P, et al. (1994). "MAGE-1 gene product is a cytoplasmic protein". Int. J. Cancer. 59 (3): 435–9. doi:10.1002/ijc.2910590324. PMID 7927954. S2CID 11410139.
• Ding M, Beck RJ, Keller CJ, Fenton RG (1994). "Cloning and analysis of MAGE-1-related genes". Biochem. Biophys. Res. Commun. 202 (1): 549–55. doi:10.1006/bbrc.1994.1963. PMID 8037761.
• Wang MG, Zakut R, Yi H, et al. (1994). "Localization of the MAGE1 gene encoding a human melanoma antigen to chromosome Xq28". Cytogenet. Cell Genet. 67 (2): 116–9. doi:10.1159/000133810. PMID 8039421.
• Becker JC, Gillitzer R, Bröcker EB (1994). "A member of the melanoma antigen-encoding gene (MAGE) family is expressed in human skin during wound healing". Int. J. Cancer. 58 (3): 346–8. doi:10.1002/ijc.2910580306. PMID 8050815. S2CID 43714786.
• Gaugler B, Van den Eynde B, van der Bruggen P, et al. (1994). "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes". J. Exp. Med. 179 (3): 921–30. doi:10.1084/jem.179.3.921. PMC 2191409. PMID 8113684.
• Chen YT, Stockert E, Chen Y, et al. (1994). "Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1004–8. Bibcode:1994PNAS...91.1004C. doi:10.1073/pnas.91.3.1004. PMC 521442. PMID 8302824.
• Rogner UC, Wilke K, Steck E, et al. (1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
• Luescher IF, Romero P, Kuznetsov D, et al. (1996). "HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA-A29, and HLA-B44". J. Biol. Chem. 271 (21): 12463–71. doi:10.1074/jbc.271.21.12463. PMID 8647853.
• Tanzarella S, Russo V, Lionello I, et al. (1999). "Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family". Cancer Res. 59 (11): 2668–74. PMID 10363990.
• Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
• Jang SJ, Soria JC, Wang L, et al. (2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959–63. PMID 11691819.
• Suyama T, Ohashi H, Nagai H, et al. (2003). "The MAGE-A1 gene expression is not determined solely by methylation status of the promoter region in hematological malignancies". Leuk. Res. 26 (12): 1113–8. doi:10.1016/S0145-2126(02)00048-6. PMID 12443884.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagao T, Higashitsuji H, Nonoguchi K, et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity". J. Biol. Chem. 278 (12): 10668–74. doi:10.1074/jbc.M206104200. hdl:2433/148472. PMID 12525503.
• Zerbini A, Pilli M, Soliani P, et al. (2004). "Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma". J. Hepatol. 40 (1): 102–9. doi:10.1016/S0168-8278(03)00484-7. PMID 14672620.
• Wang LP, Chen HS, Mei MH, et al. (2004). "[The genetic polymorphism of melanoma-associated antigen 1 in Chinese normal donors and hepatoma patients]". Zhonghua Gan Zang Bing Za Zhi. 12 (3): 151–5. PMID 15059299.

External links

• Overview of all the structural information available in the PDB for UniProt: P43355 (Melanoma-associated antigen 1) at the PDBe-KB.