Liver X receptor beta

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).^[5]

NR1H2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V,%%s4NQA
Identifiers
Aliases	NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR, Liver X receptor beta, nuclear receptor subfamily 1 group H member 2
External IDs	OMIM: 600380; MGI: 1352463; HomoloGene: 21397; GeneCards: NR1H2; OMA:NR1H2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,329,653 bp[1] End 50,383,388 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,199,040 bp[2] End 44,203,375 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery thoracic aorta left coronary artery ascending aorta Descending thoracic aorta gastric mucosa gastrocnemius muscle muscle of thigh Top expressed in granulocyte neural layer of retina lip muscle of thigh right kidney superior frontal gyrus duodenum thymus esophagus ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity ATPase binding zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding retinoid X receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding steroid hormone receptor activity apolipoprotein A-I receptor binding nuclear receptor activity protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor binding nuclear receptor coactivator activity signaling receptor activity Cellular component cytoplasm nucleoplasm nucleus RNA polymerase II transcription regulator complex Biological process positive regulation of high-density lipoprotein particle assembly negative regulation of proteolysis positive regulation of triglyceride biosynthetic process positive regulation of protein metabolic process negative regulation of interferon-gamma-mediated signaling pathway positive regulation of cholesterol transport regulation of transcription, DNA-templated cellular lipid metabolic process regulation of transcription by RNA polymerase II positive regulation of secretion of lysosomal enzymes positive regulation of lipid storage positive regulation of lipoprotein lipase activity negative regulation of transcription by RNA polymerase II positive regulation of fatty acid biosynthetic process negative regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of cholesterol storage negative regulation of pinocytosis positive regulation of gene expression retinoic acid receptor signaling pathway positive regulation of cholesterol efflux positive regulation of pancreatic juice secretion lipid homeostasis negative regulation of lipid transport transcription initiation from RNA polymerase II promoter negative regulation of transcription, DNA-templated negative regulation of macrophage derived foam cell differentiation positive regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway cholesterol homeostasis lipid metabolism multicellular organism development cell differentiation cellular response to lipopolysaccharide negative regulation of cold-induced thermogenesis intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7376 22260 Ensembl ENSG00000131408 ENSMUSG00000060601 UniProt P55055 Q60644 RefSeq (mRNA) NM_007121 NM_001256647 NM_001285517 NM_001285518 NM_001285519 NM_009473 RefSeq (protein) NP_001243576 NP_009052 NP_009052.3 NP_001272446 NP_001272447 NP_001272448 NP_033499 Location (UCSC) Chr 19: 50.33 – 50.38 Mb Chr 7: 44.2 – 44.2 Mb PubMed search [3] [4]
Wikidata
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Function

The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins.^[5][6]

Structure

Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element.^[7]

Interactions

Liver X receptor beta has been shown to interact with NCOA6^[8] and Retinoid X receptor alpha.^[9]