There are many creatures in the mythology, folklore, and fiction of many cultures who are one-eyed, this page lists such one-eyed creatures.
- Arimaspi, legendary people of northern Scythia, "always at war with their neighbours" and stealing gold from griffins. They had a single eye in the centre of the forehead.
- Balor, a giant in Irish mythology, with one eye in his forehead that would wreak destruction when opened
- Bungisngis, one-eyed giants of Philippine folklore
- Cyclopes (singular: Cyclops), one-eyed giants in Greek mythology, including Polyphemus. They had a single eye in the centre of their forehead.
- Dajjal, a figure in Islam akin to the Antichrist, who has one eye
- Duwa Sokhor, an ancestor of Genghis Khan, according to The Secret History of the Mongols, who had one eye in his forehead[1]
- Fachan, a creature from Celtic mythology with one eye, one arm and one leg
- The Eye of Providence is a representation of Divine Providence
- The Graeae, the three witches (or sisters) that shared one eye and one tooth between them; often depicted as clairvoyant. They were forced by Perseus, by stealing their eye, into revealing the location of Medusa.
- Hagen or Högni, a Burgundian warrior in German and Norse legend, depicted as one-eyed in some accounts
- Some yokais, in the Japanese folklore, have a single giant eye:
- Jian, a bird in Chinese mythology with only one eye and one wing. A pair of such birds were dependent on each other and inseparable.
- Kabandha, a demon with no head or neck with one large eye on the breast and a mouth on the stomach. Kabandha appears in Hindu mythology as a character in the Ramayana.
- Likho, an embodiment of evil fate and misfortune in Slavic mythology
- Mapinguari, giant sloth-like cryptid of Brazil and Bolivia often described as having one eye
- Odin, a Norse god (he was born with two eyes, but traded one for a drink from Mimir's well)
- Ojáncanu, one-eyed giant with a ten-fingered hand, a ten-toed foot, a long beard and red hair of Cantabrian mythology who embodies evil, cruelty and brutality
- One-Eye
- Papinijuwari, Australian sky deities with vampiric tendencies
- Popobawa, a Tanzanian shetani (evil spirit) that often takes the form of a one-eyed bat-like creature
- Psoglav, a one-eyed dog-headed monster in Serbian mythology
- Snallygaster, a one-eyed dragon-like creature said to inhabit the hills surrounding Washington, D.C. and Frederick County, Maryland
- Tepegoz, a one-eyed ogre in the Oghuz Turkish epic Book of Dede Korkut
- Ra, an Egyptian god whose right eye represents life, immortality, and light, often portrayed as a sun
- Horus, an Egyptian god whose left eye represents the moon, healing, protection, and restoration
Science fiction
- Alpha Centauri, a green hermaphrodite hexapod with one huge eye; Doctor Who character first seen in The Curse of Peladon
- Cylon Centurions in sci-fi franchise Battlestar Galactica
- The Cyclops (1957), a science fiction horror film about a creature created via radiation exposure
- Dalek Sec, a monster that became a one-eyed Dalek-human hybrid in Doctor Who
- Gigan from the Godzilla series, a one-eyed alien cyborg Kaiju
- Kerack, an alien race resembling large one-eyed prawns in the novel Camelot 30K
- Magnus the Red, the one-eyed primarch of the Thousand Sons legion in Warhammer 40,000
- Monoids, an alien race in the 1966 Doctor Who serial The Ark
- Myo and other Abyssin aliens in Star Wars
- Naga and his tribe of one-eyed violent mutants in the 1956 B-movie World Without End
- Old One Eye, a unique Tyranid carnifex with the ability to rapidly regenerate from mortal wounds in Warhammer 40k
- One-eyed, starfish-shaped aliens from the planet Paira in the 1956 Japanese film Warning from Space
- Ravage, a panther-like Decepticon in Transformers: Revenge of the Fallen
- Scaroth, last of the Jagaroth, a time-travelling alien in the 1979 Doctor Who story City of Death
- Uniocs, an alien race in the webcomic Schlock Mercenary
- Leela from Futurama
Historical and mythological fantasy
- Beholder, a creature in the role-playing game Dungeons & Dragons with one large eye and many smaller eyestalks
- Cyclops in the role-playing game Dungeons & Dragons
- Draken, a one-eyed sea monster in the animated series Jumanji
- Imbra, an idol and the highest god of Kafiristan in Rudyard Kipling's The Man Who Would Be King
- Medusa in the Italian film Medusa Against the Son of Hercules, adapted for television as one episode of the series The Sons of Hercules
- Rell, a cyclops in the film Krull. The Cyclops traded with the Beast one of their eyes for the ability to see into the future. The Beast did give them the ability to see into the future – but they can only see the moment of their own deaths.
- Sauron, the eponymous arch-villain of The Lord of the Rings, often depicted as looking through a single 'Eye' in Peter Jackson's cinematic adaptations of Tolkien's work
- Tyson, Percy Jackson's half-brother in Percy Jackson and the Olympians, is a Cyclops. Cyclopes also appear as villains.
- Zargon, a giant one-eyed monster in the role-playing game Dungeons & Dragons
Animation and puppetry
- Ahgg, the witches' giant spider with one eye in the center of his forehead in My Little Pony: The Movie
- Some of the characters in Ben 10
- Bill Cipher, an evil yellow eye of providence-like entity in Gravity Falls
- Big Billy in The Powerpuff Girls who showed that he had one eye in the episode "School House Rocked"
- B.O.B. (Bicarbonate Ostylezene Benzoate), a gelatinous creature in Monsters vs. Aliens
- The Centaur Monster with a body of a centaur in TMNT (2007)
- Horvak, Krumm's father from Aaahh!!! Real Monsters
- Kang and Kodos, a recurring alien duo in the animated series The Simpsons
- Leela, a mutant character, as well as her parents Munda and Morris, in the animated series Futurama
- Some of the Minions, comic henchmen in the Despicable Me franchise
- Muno, a tall, red monster with one large eye, in the children's television series Yo Gabba Gabba!
- Sheldon Plankton in the animated children's series SpongeBob SquarePants
- Agent Pleakley in the 2002 animated film Lilo & Stitch
- Sapphire in the Cartoon Network animated series Steven Universe
- Mike Wazowski, a round monster with one large eye on the breast and a mouth on the stomach. He appears in the 2001 animated film Monsters, Inc.
- Zatar the Alien, a green alien in the MTV series Celebrity Deathmatch
- Tri-Klops, a henchman of the villain Skeletor in the children's show He-Man and the Masters of the Universe
- Rob, an anthropomorph cyclop boy in the animated show The Amazing World of Gumball
- Kyle, the owner of the Queen's Goiter, and Cloppy, Evan's one-eyed monster doll from The Barbarian and the Troll
Anime and manga
- Lord Boros, in One-Punch Man, the alien leader of the Dark Matter Thieves, self-proclaimed subjugator of the universe, and the first antagonist to give Saitama a "serious fight"
- Norman Burg, the butler and weapons specialist to Roger Smith in The Big O
- Darklops Zero, prototype of Darklops in the film Ultraman Zero: The Revenge of Belial
- Iwanaga Kotoko, in In/Spectre, A 17-year-old Goddess Of Wisdom to the spirits and humans alike, has only one eye and one leg due to sacrificing a part of her to become a goddess.
- Manako, a cyclops sniper in Monster Musume
- Hitomi Manaka, cyclops school nurse and protagonist of Nurse Hitomi's Monster Infirmary
- Mannequin soldiers, lesser homunculi created by a government project in Fullmetal Alchemist