Since 1879, the four arenas known as Madison Square Garden have hosted many sporting events, concerts, and political rallies.
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Madison Square Garden was one of the primary centers of the boxing universe throughout its history and in all of its incarnations before Las Vegas became the sport's main center starting in the 1980s. However, MSG still hosts many significant fights. Some of the historic fights held at MSG have been:
- October 26, 1951 — Rocky Marciano vs. Joe Louis
- The unbeaten Marciano, who would become heavyweight champion the following year, knocked out a clearly past-his-prime Louis in the 8th round. After the loss, Louis retired for the second time, this time for good.
- Two of the three Ali–Frazier fights:
- March 8, 1971 — Fight of the Century
- One of the most hyped fights in history, with both heavyweight champion Frazier and challenger Ali entering unbeaten. Frazier won by unanimous decision.
- January 28, 1974 — Ali-Frazier II
- Ali avenges his loss to Frazier, also by unanimous decision.
- June 13, 1986 — Héctor Camacho vs. Edwin Rosario
- A classic showdown between Puerto Rican stars Héctor Camacho and Edwin Rosario for Camacho's lightweight title, with Camacho retaining his title by a controversial split decision.
- July 11, 1996 — Riddick Bowe vs. Andrew Golota
- Though ahead on points, Golota was penalized several times for low blows, and was finally disqualified in the seventh round after a volley of punches to Bowe's testicles. Seconds after Golota was disqualified, Bowe's entourage rushed the ring, attacked Golota with a two way radio, and assaulted Golota's 74-year-old trainer Lou Duva. The entourage began rioting, fighting with spectators, staff and policemen alike, resulting in a number of injuries before they were forced out of the arena in what evolved into a lengthy televised ring spectacle.
- September 29, 2001 — The final bout of the Middleweight World Championship Series, in which Bernard Hopkins defeated Félix Trinidad by 12th-round TKO to claim the undisputed title.
- October 2, 2004 — Félix Trinidad vs. Ricardo Mayorga
- Trinidad returned from a two-year layoff and defeated Ricardo Mayorga by TKO in the 8th round.
- November 8, 2008 — Joe Calzaghe vs. Roy Jones Jr.
- June 1, 2019 — Anthony Joshua vs. Andy Ruiz Jr.
- After coming in as a 25-1 underdog, Ruiz won the match via technical knockout in the seventh round, ending Joshua's undefeated record and becoming the new unified heavyweight champion.
- April 30, 2022 — Katie Taylor vs. Amanda Serrano
- First women's boxing match to headline Madison Square Garden. In what was described as the 'biggest women's fight of all time', Taylor defeated Serrano by split decision, remaining the undisputed lightweight champion.
After the New York State Athletic Commission authorized mixed martial events in 2016, the MSG has hosted multiple major bouts:
- November 12, 2016 — UFC 205: Alvarez vs. McGregor
- June 24, 2017 — Bellator NYC/Bellator 180
- November 4, 2017 — UFC 217: Bisping vs. St-Pierre
- November 3, 2018 — UFC 230: Cormier vs. Lewis
- June 14, 2019 — Bellator 222
- November 2, 2019 — UFC 244: Masvidal vs. Diaz
- November 6, 2021 — UFC 268: Usman vs. Covington 2
- November 12, 2022 — UFC 281: Adesanya vs. Pereira
- November 11, 2023 — UFC 295: Procházka vs. Pereira
- November 16, 2024 — UFC 309: Jones vs. Miocic