This is a list of notable Maltese people including those not born in, or current residents of, Malta; they are Maltese nationals.
- Sebastian Calleja (born 1998) – singer; winner OGAE Eurovision Weekend 2016 Berlin, Germany
- Gianluca Bezzina (born 1989) – singer; medical doctor
- Nicky Bomba (born 1963) – drummer; leads the Australian funk and reggae band Bomba.
- Amber Bondin (born 1991) – singer
- Gerard James Borg – songwriter
- Kevin Borg (born 1986) – singer-songwriter; producer; winner of the Swedish reality-competition talent show Idol 2008
- Joe C. (1974–2000) – rapper; of Maltese descent
- Joseph Calleja (born 1978) – tenor singer
- Kurt Calleja (born 1989) – singer
- Joe Camilleri (born 1948) – singer-songwriter; saxophonist
- Pawlu Camilleri (born 1958) – harmonica musician
- Capitol K – musician
- Lydia Caruana – soprano
- Eleanor Cassar (born 1982) – singer
- Gaia Cauchi (born 2002) – child singer, winner of the Junior Eurovision Song Contest 2013
- Lynn Chircop (born 1980) – singer and television presenter
- Miriam Christine (born 1978) – singer
- Destiny Chukunyere (born 2002) – singer, winner of the Junior Eurovision Song Contest 2015
- Federica Falzon (born 2003) – operatic pop singer
- Claudia Faniello (born 1988) – singer
- Fabrizio Faniello (born 1981) – singer
- Miriam Gauci – opera singer
- Natalie Gauci (born 1981) – singer
- Ludwig Galea (born 1977) – singer
- Robert Galea (born 1981) – Christian singer-songwriter
- Stefan Galea (born 1996) – singer
- Thea Garrett (born 1992) – singer
- Albert Garzia (born 1977) – composer and musician
- Lawrence Gray (born 1975) – singer
- Joe Grech (born 1934) – singer-songwriter
- Martin Grech (born 1983) – singer-songwriter
- Enzo Gusman (1947-2021) broadcaster – singer-songwriter
- Sarah Harrison (born 1993) – singer, DJ, producer, musician
- Hooligan (born 1980) – rapper
- Rosa Judge (born 1919) – musician
- Oreste Kirkop (1923–1998) – opera singer; film actor
- La Barokka – singer
- Olivia Lewis (born 1978) – singer
- Ira Losco (born 1981) – singer-songwriter
- William Mangion (born 1958) – singer
- Walter Micallef (born 1955) – singer-songwriter
- Renato Micallef (born 1951) – pop singer
- Anthony J. Mifsud – singer-songwriter
- Sigmund Mifsud – trumpeter, CEO Malta Philharmonic Orchestra
- Antoinette Miggiani (born 1937) – opera singer
- Morena (born 1984) – singer
- Brent Muscat (born 1967) – guitarist
- Emma Muscat (born 1999) singer, model (from one of Malta's wealthiest families)
- Muxu (born 1990) – singer-songwriter
- Gabriela N (born 1993) – singer-songwriter
- Antonio Olivari (born 1980) – songwriter and composer
- Claudette Pace (born 1968) – singer and politician
- Freddie Portelli (born 1944) – singer-songwriter
- Jes Psaila (born 1964) – guitarist
- Veronica Rotin (born 2004) – child singer
- Roger Scannura – flamenco guitarist
- Christabelle (born 1992) – singer-songwriter
- Debbie Scerri (born 1969) – singer and television presenter
- Chiara Siracusa (born 1976) – singer
- Mary Spiteri (born 1947) – singer
- Renzo Spiteri – percussionist
- Sharleen Spiteri (born 1967) – singer-songwriter; guitarist; lead vocalist of the Scottish pop-rock band Texas
- Marc Storace (born 1949) – singer of the Swiss hard-rock band Krokus
- Daniel Testa (born 1997) – singer, radio and television presenter
- Melissa Tkautz (born 1974) – singer
- Glen Vella (born 1983) – singer
- Mario Vella (born 1976) – singer and songwriter, frontman of Brikkuni
- Philip Vella
- Julie Zahra (born 1982) – singer, member Parliament of Malta
- Aidan Zammit (born 1965) – composer, musician and singer
- George Abela (born 1948) – President of Malta (2009–2014)
- Robert Abela (born 1977) – Prime Minister of Malta (since 2020)
- Wistin Abela (1933–2014) – Deputy Prime Minister of Malta (1981–1983)
- Eddie Fenech Adami (born 1934) – Prime Minister of Malta (1987–1996, 1998–2004); President of Malta (2004–2009)
- John Aquilina (born 1950) – Australian politician and Maltese diplomat
- Agatha Barbara (1923–2002) – government minister; member, Parliament of Malta; President of Malta (1982–1987)
- Claudette Abela Baldacchino (born 1973), journalist, Labour Party politician and Member of the European Parliament
- Leo Brincat – Member of the European Court of Auditors
- Paul Boffa (1890–1962) – Prime Minister of Malta (1947–1950)
- Joe Borg (born 1952) – European Commissioner for Maritime Affairs and Fisheries; European Commissioner for Humanitarian Aid and Civil Protection
- Tonio Borg (born 1957) – European Commissioner for Health and Consumer Policy
- George Borg Olivier (1911–1980) – Prime Minister of Malta (1950–1955, 1962–1971)
- Francesco Buhagiar (1876–1934) – Prime Minister of Malta (1923–1924)
- Simon Busuttil (born 1969) – leader, Nationalist Party (2013-2017), Member of European Parliament (2004-2013)
- Anton Buttigieg (1912–1983) – President of Malta (1976–1981)
- Arnold Cassola (born 1956) – professor of comparative literature; former chairperson, Democratic Alternative
- Joseph Cefai (1921–1996) – member, Parliament of Malta (1947–1953); Secretary of Gozo Affairs (until 1981)
- Marie Louise Coleiro Preca (born 1958) – President of Malta (since 2014)
- John Dalli (born 1948) – European Commissioner for Health and Consumer Policy (2010–2012)
- Joe Debono Grech (born 1939) – member, Parliament of Malta (since 1971)
- Guido de Marco (1931–2010) – Deputy Prime Minister of Malta; President of Malta (1999–2004)
- Manwel Dimech (1860–1921) – politician; social reformer; philosopher; journalist; writer
- Cyrus Engerer (born 1981) – Member of European Parliament (2020-present)
- Giovanni Felice (1899–1977) – Minister of Industry and Tourism (1962–1966); Finance Minister of Malta (1966–1971) in the Giorgio Borġ Olivier cabinet
- Joseph Flores (1907–1974) – Speaker of the House of Representatives of Malta; judge
- Lawrence Gonzi (born 1953) – Prime Minister of Malta (2004–2013)
- Louis Grech (born 1947) – Deputy Prime Minister of Malta (since 2013)
- Joseph Howard (1862–1925) – Prime Minister of Malta (1921–1923)
- Albert Hyzler (1916–1993) – Acting President of Malta (1981–1982)
- Norman Lowell (born 1946) – founder and leader, Imperium Europa
- Anthony Mamo (1909–2008) – Governor-General of Malta (1971–1974); President of Malta (1974–1976)
- Francesco Masini (1894–1964) – founder, Gozo Party; member, Parliament of Malta (1947–1950)
- Sir Ugo Pasquale Mifsud (1889–1942) – Prime Minister of Malta (1932–1933)
- Karmenu Mifsud Bonnici (born 1933) – Prime Minister of Malta (1984–1987)
- Ugo Mifsud Bonnici (born 1932) – government minister; President of Malta (1994–1999)
- Dom Mintoff (1916–2012) – Prime Minister of Malta (1955–1958, 1971–1984)
- Enrico Mizzi (1885–1950) – Prime Minister of Malta (1950)
- Joseph Muscat (born 1974) – Member of the European Parliament (2004–2008); leader, Labour Party (2008–2020), Prime Minister of Malta (2013–2020)
- Alfred Sant (born 1948) – Prime Minister of Malta (1996–1998)
- Lorry Sant (1937–1995) – government minister
- Carm Lino Spiteri (1932–2008) – Nationalist Party politician
- Gerald Strickland (1861–1940) – Prime Minister of Malta (1927–1932); Governor of Tasmania; Governor of Western Australia; Governor of New South Wales
- Mabel Strickland, journalist, newspaper proprietor and politician, daughter of the above
- Ċensu Tabone (1913–2012) – government minister; President of Malta (1989–1994)
- George William Vella (born 1942) – government minister; Deputy Prime Minister of Malta (1996–1998)
- Paul Xuereb (1923–1994) – Speaker of the House of Representatives of Malta (1986–1987); Acting President of Malta (1987–1989)