Levonadifloxacin

Levonadifloxacin
Clinical data
Trade names	Emrok
Other names	(S)-(-)-Nadifloxacin
Routes of; administration	Parenteral
ATC code	J01MA24 (WHO) ;
Legal status
Legal status	Rx in India;
Identifiers
	IUPAC name (12S)-7-Fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid;
CAS Number	154357-42-3;
PubChem CID	9850038;
UNII	8WHH66L098;
ChEBI	CHEBI:37908;
ChEMBL	ChEMBL190561;
CompTox Dashboard (EPA)	DTXSID70165599 ;
Chemical and physical data
Formula	C19H21FN2O4
Molar mass	360.385 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O;
	InChI InChI=InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)/t10-/m0/s1; Key:JYJTVFIEFKZWCJ-JTQLQIEISA-N;

Levonadifloxacin (trade name Emrok) is an antibiotic drug of the fluoroquinolone class.^[1]^[2] Chemically, it is the (S)-enantiomer of the racemic drug nadifloxacin.

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It is approved in India for the treatment of skin and soft tissue infections of Gram-positive bacteria.^[3] It is also being studied for potential use against resistant strains of bacteria including Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis.^[4]

Levonadifloxacin has poor oral bioavailability. A prodrug of levonadifloxacin with high oral bioavailability, alalevonadifloxacin, has been developed to mitigate this problem.^[5]

References