Leucine carboxyl methyltransferase 1

Leucine carboxyl methyltransferase 1 is an enzyme that in humans is encoded by the LCMT1 gene.^[5][6]

LCMT1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3IEI, 3O7W, 3P71
Identifiers
Aliases	LCMT1, LCMT, PPMT1, CGI-68, leucine carboxyl methyltransferase 1
External IDs	OMIM: 610286; MGI: 1353593; HomoloGene: 41123; GeneCards: LCMT1; OMA:LCMT1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 25,111,731 bp[1] End 25,178,231 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 122,969,007 bp[2] End 123,029,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus body of pancreas prefrontal cortex oocyte nucleus accumbens right frontal lobe gonad Pons Brodmann area 23 anterior cingulate cortex Top expressed in lacrimal gland dentate gyrus of hippocampal formation granule cell Region I of hippocampus proper ventromedial nucleus medial ganglionic eminence anterior amygdaloid area nucleus accumbens nucleus of stria terminalis dorsomedial hypothalamic nucleus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity protein methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity transferase activity protein binding protein C-terminal carboxyl O-methyltransferase activity protein C-terminal leucine carboxyl O-methyltransferase activity Cellular component cytosol nucleoplasm Biological process regulation of mitotic cell cycle spindle assembly checkpoint methylation C-terminal protein methylation regulation of glucose metabolic process regulation of apoptotic process negative regulation of protein-containing complex assembly protein methylation G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51451 30949 Ensembl ENSG00000205629 ENSMUSG00000030763 UniProt Q9UIC8 n/a RefSeq (mRNA) NM_001032391 NM_016309 NM_016015 NM_025304 NM_001355050 RefSeq (protein) NP_001027563 NP_057393 n/a Location (UCSC) Chr 16: 25.11 – 25.18 Mb Chr 7: 122.97 – 123.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

LCMT1 has been shown to interact with FXR2.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000205629 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030763 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. "Entrez Gene: LCMT1 leucine carboxyl methyltransferase 1".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

• Lee JA, Pallas DC (Oct 2007). "Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells". The Journal of Biological Chemistry. 282 (42): 30974–84. doi:10.1074/jbc.M704861200. PMC 3516869. PMID 17724024.
• De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J (Dec 1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.