Latrophilin 3

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.^[5][6]

ADGRL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CMN, 5AFB
Identifiers
Aliases	ADGRL3, CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDs	OMIM: 616417; MGI: 2441950; HomoloGene: 22878; GeneCards: ADGRL3; OMA:ADGRL3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.1 Start 61,201,258 bp[1] End 62,078,335 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 D-E1 Start 81,020,138 bp[2] End 81,825,133 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle saphenous vein middle temporal gyrus endothelial cell entorhinal cortex pars compacta superior vestibular nucleus orbitofrontal cortex Achilles tendon Brodmann area 23 Top expressed in Region I of hippocampus proper otolith organ utricle ventromedial nucleus substantia nigra anterior amygdaloid area lateral septal nucleus lateral hypothalamus medial geniculate nucleus olfactory tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity metal ion binding protein binding transmembrane signaling receptor activity carbohydrate binding calcium ion binding Cellular component integral component of membrane cell projection membrane cell-cell junction plasma membrane axon cell junction integral component of plasma membrane glutamatergic synapse intracellular anatomical structure Biological process response to cocaine G protein-coupled receptor signaling pathway neuron migration cell surface receptor signaling pathway synapse assembly locomotion involved in locomotory behavior signal transduction positive regulation of synapse assembly cell-cell adhesion via plasma-membrane adhesion molecules synapse organization adenylate cyclase-activating G protein-coupled receptor signaling pathway brain development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23284 319387 Ensembl ENSG00000150471 ENSMUSG00000037605 UniProt Q9HAR2 Q80TS3 RefSeq (mRNA) NM_015236 NM_001322246 NM_001322402 NM_001371342 NM_001371343 NM_001371344 NM_001371345 NM_001371346 NM_198702 NM_001347367 NM_001347368 NM_001347369 NM_001347371 NM_001359826 NM_001359828 NM_001359829 NM_001359830 NM_001359831 NM_001359832 NM_001359833 NM_001359834 RefSeq (protein) NP_001309175 NP_001309331 NP_056051 NP_001358271 NP_001358272 NP_001358273 NP_001358274 NP_001358275 NP_001334296 NP_001334297 NP_001334298 NP_001334300 NP_941991 NP_001346755 NP_001346757 NP_001346758 NP_001346759 NP_001346760 NP_001346761 NP_001346762 NP_001346763 Location (UCSC) Chr 4: 61.2 – 62.08 Mb Chr 5: 81.02 – 81.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.^[6]

Clinical significance

A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD).^[7]

See also

• Adhesion G protein-coupled receptors

References

1. GRCh38: Ensembl release 89: ENSG00000150471 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037605 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.
6. "LPHN3 latrophilin 3". Entrez Gene. U.S. National Library of Medicine.
7. Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (November 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication". Molecular Psychiatry. 15 (11): 1053–1066. doi:10.1038/mp.2010.6. hdl:11336/80502. PMID 20157310.

Further reading

• Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24: 933–962. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
• Ushkaryov YA, Volynski KE, Ashton AC (April 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–542. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
• Soares MB, Bonaldo MF, Jelene P, Su L, Lawton L, Efstratiadis A (September 1994). "Construction and characterization of a normalized cDNA library". Proceedings of the National Academy of Sciences of the United States of America. 91 (20): 9228–9232. Bibcode:1994PNAS...91.9228S. doi:10.1073/pnas.91.20.9228. PMC 44785. PMID 7937745.
• The Sanger Centre, The Washington University Genome Sequencing Center (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, et al. (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (October 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–32390. doi:10.1074/jbc.C000490200. PMID 10964907.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3

This article incorporates text from the United States National Library of Medicine, which is in the public domain.