LYPD3

Ly6/PLAUR domain-containing protein 3 is a protein that in humans is encoded by the LYPD3 gene.^[5][6][7]

LYPD3
Identifiers
Aliases	LYPD3, C4.4A, LY6/PLAUR domain containing 3
External IDs	OMIM: 609484; MGI: 1919684; HomoloGene: 8672; GeneCards: LYPD3; OMA:LYPD3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.31 Start 43,460,787 bp[1] End 43,465,608 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 24,335,975 bp[2] End 24,340,543 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium mucosa of pharynx skin of abdomen nipple skin of arm vulva human penis skin of leg skin of thigh body of tongue Top expressed in lip esophagus hair follicle skin of external ear skin of abdomen zygote skin of back conjunctival fornix primary oocyte transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function laminin binding Cellular component integral component of membrane anchored component of membrane anchored component of plasma membrane membrane extracellular region extracellular space plasma membrane Biological process cell-matrix adhesion C-terminal protein lipidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27076 72434 Ensembl ENSG00000124466 ENSMUSG00000057454 UniProt O95274 Q91YK8 RefSeq (mRNA) NM_014400 NM_133743 RefSeq (protein) NP_055215 NP_598504 Location (UCSC) Chr 19: 43.46 – 43.47 Mb Chr 7: 24.34 – 24.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000124466 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057454 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wurfel J, Seiter S, Stassar M, Claas A, Klas R, Rosel M, Marhaba R, Savelyeva L, Schwab M, Matzku S, Zoller M (Feb 2001). "Cloning of the human homologue of the metastasis-associated rat C4.4A". Gene. 262 (1–2): 35–41. doi:10.1016/S0378-1119(00)00515-1. PMID 11179665.
6. Smith BA, Kennedy WJ, Harnden P, Selby PJ, Trejdosiewicz LK, Southgate J (Mar 2001). "Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium". Cancer Res. 61 (4): 1678–85. PMID 11245483.
7. "Entrez Gene: LYPD3 LY6/PLAUR domain containing 3".

Further reading

• Paret C, Hildebrand D, Weitz J, et al. (2007). "C4.4A as a candidate marker in the diagnosis of colorectal cancer". Br. J. Cancer. 97 (8): 1146–56. doi:10.1038/sj.bjc.6604012. PMC 2360445. PMID 17912244.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Hansen LV, Gårdsvoll H, Nielsen BS, et al. (2004). "Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor". Biochem. J. 380 (Pt 3): 845–57. doi:10.1042/BJ20031478. PMC 1224211. PMID 15012588.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Fletcher GC, Patel S, Tyson K, et al. (2003). "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan". Br. J. Cancer. 88 (4): 579–85. doi:10.1038/sj.bjc.6600740. PMC 2377166. PMID 12592373.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Adam PJ, Boyd R, Tyson KL, et al. (2003). "Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer". J. Biol. Chem. 278 (8): 6482–9. doi:10.1074/jbc.M210184200. PMID 12477722.