LYPD1

Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene.^[5][6]

LYPD1
Identifiers
Aliases	LYPD1, LYPDC1, PHTS, LY6/PLAUR domain containing 1
External IDs	OMIM: 610450; MGI: 1919835; HomoloGene: 16937; GeneCards: LYPD1; OMA:LYPD1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q21.2 Start 132,643,286 bp[1] End 132,671,579 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E3 Start 125,795,359 bp[2] End 125,840,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube nucleus accumbens caudate nucleus putamen ventricular zone Hypothalamus Amygdala Pituitary Gland cingulate gyrus anterior cingulate cortex Top expressed in glossopharyngeal ganglion ganglion of vagus nerve dentate gyrus of hippocampal formation granule cell cuneiform bones cranial nervi inferior ganglion of vagus nerve Amygdala olfactory nerve primary visual cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine receptor binding acetylcholine receptor inhibitor activity Cellular component membrane anchored component of membrane extracellular region plasma membrane Biological process response to nicotine behavioral fear response negative regulation of signaling receptor activity synaptic transmission, cholinergic cell activation acetylcholine receptor signaling pathway negative regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116372 72585 Ensembl ENSG00000150551 ENSMUSG00000026344 UniProt Q8N2G4 Q8BLC3 RefSeq (mRNA) NM_001077427 NM_144586 NM_001321234 NM_001321235 NM_145100 NM_001311089 NM_001311090 RefSeq (protein) NP_001070895 NP_001308163 NP_001308164 NP_653187 NP_001298018 NP_001298019 NP_659568 Location (UCSC) Chr 2: 132.64 – 132.67 Mb Chr 1: 125.8 – 125.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins.^[7] Transgenic mice without Lynx2 expression have increased anxiety-related behaviors.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000150551 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026344 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: LYPD1 LY6/PLAUR domain containing 1".
7. Miwa, J. M.; Lester, H. A.; Walz, A. (2012). "Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction". Physiology. 27 (4): 187–199. doi:10.1152/physiol.00002.2012. PMID 22875450.
8. Tekinay, A. B.; Nong, Y.; Miwa, J. M.; Lieberam, I.; Ibanez-Tallon, I.; Greengard, P.; Heintz, N. (2009). "A role for LYNX2 in anxiety-related behavior". Proceedings of the National Academy of Sciences. 106 (11): 4477–4482. Bibcode:2009PNAS..106.4477T. doi:10.1073/pnas.0813109106. PMC 2657456. PMID 19246390.

Further reading

• Yu DH, Fan W, Liu G, et al. (2006). "PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway". Exp. Cell Res. 312 (6): 865–76. doi:10.1016/j.yexcr.2005.12.006. PMID 16413018.
• Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.