LY6E

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.^[5][6][7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.^[8] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.^[9] Further research is required to validate Ly6E for translation research.

LY6E
Identifiers
Aliases	LY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDs	OMIM: 601384; MGI: 106651; HomoloGene: 56411; GeneCards: LY6E; OMA:LY6E - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 143,017,982 bp[1] End 143,023,832 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D3|15 34.29 cM Start 74,826,900 bp[2] End 74,831,754 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver granulocyte olfactory zone of nasal mucosa stromal cell of endometrium placenta right ovary right lung upper lobe of left lung right frontal lobe hippocampus proper Top expressed in lactiferous gland superior surface of tongue gallbladder corneal stroma cardiac muscles cardiac muscle tissue of left ventricle CA3 field right kidney perirhinal cortex esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine receptor inhibitor activity Cellular component integral component of plasma membrane membrane anchored component of membrane extracellular region plasma membrane Biological process cell surface receptor signaling pathway negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4061 17069 Ensembl ENSG00000278032 ENSG00000160932 ENSMUSG00000022587 UniProt Q16553 Q64253 RefSeq (mRNA) NM_002346 NM_001127213 NM_001164036 NM_001164037 NM_001164038 NM_001164039 NM_001164040 NM_008529 NM_001374138 RefSeq (protein) NP_001120685 NP_002337 NP_001157508 NP_001157509 NP_001157510 NP_001157511 NP_001157512 NP_032555 NP_001361067 Location (UCSC) Chr 8: 143.02 – 143.02 Mb Chr 15: 74.83 – 74.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000160932 GRCh38: Ensembl release 89: ENSG00000278032, ENSG00000160932 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022587 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. doi:10.4049/jimmunol.157.3.969. PMID 8757598.
6. Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. Bibcode:1996PNAS...93.5910M. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192.
7. "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E".
8. Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y, Upadhyay G (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7 (10): 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465. PMID 26862846.
9. Hossiny MA, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G (2016-04-11). "Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76 (11): 3376–3386. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472. PMC 4910623. PMID 27197181.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB (1997). "A gain of novel tissue specificity in the human Ly-6 gene E48". J. Immunol. 159 (10): 4879–86. doi:10.4049/jimmunol.159.10.4879. PMID 9366413.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Shan X, Bourdeau A, Rhoton A, Wells DE, Cohen EH, Landgraf BE, Palfree RG (1998). "Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1". J. Immunol. 160 (1): 197–208. doi:10.4049/jimmunol.160.1.197. PMID 9551972.
• Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T (1998). "Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex". J. Biol. Chem. 273 (20): 12301–6. doi:10.1074/jbc.273.20.12301. PMID 9575182.
• Ding L, Shevach EM (2001). "Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen". Immunology. 104 (1): 28–36. doi:10.1046/j.1365-2567.2001.01275.x. PMC 1783287. PMID 11576217.
• Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ (2002). "Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland". Mol. Cell. Biol. 22 (3): 946–52. doi:10.1128/MCB.22.3.946-952.2002. PMC 133557. PMID 11784869.
• de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB, Brakenhoff RH (2003). "Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma". Int. J. Cancer. 103 (6): 768–74. doi:10.1002/ijc.10903. PMID 12516096. S2CID 42182637.