LY-255582

LY-255582 is a phenylpiperidine non-selective opioid antagonist. It has been shown to reduce ethanol consumption in experiments carried out on rats.^[1] It has also been shown to reduce food and water consumption in rats.^[2]

LY-255582

Names
Preferred IUPAC name 3-{(3R,4R)-1-[(3S)-3-Cyclohexyl-3-hydroxypropyl]-3,4-dimethylpiperidin-4-yl}phenol
Identifiers
CAS Number	119193-09-8
3D model (JSmol)	Interactive image
ChemSpider	8081850
PubChem CID	9906198
CompTox Dashboard (EPA)	DTXSID201045752
InChI InChI=1S/C22H35NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h6,9-10,15,17-18,21,24-25H,3-5,7-8,11-14,16H2,1-2H3/t17-,21-,22+/m0/s1 Key: LVVHEFJXPXAUDD-BULFRSBZSA-N InChI=1/C22H35NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h6,9-10,15,17-18,21,24-25H,3-5,7-8,11-14,16H2,1-2H3/t17-,21-,22+/m0/s1 Key: LVVHEFJXPXAUDD-BULFRSBZBD
SMILES C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CC[C@@H](C3CCCCC3)O
Properties
Chemical formula	C22H35NO2
Molar mass	345.527 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

See also

• κ-Opioid receptor § Antagonists
• List of investigational antidepressants

References

1. Dhaher R, et al. (Feb 2012). "Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats". Alcohol (Fayetteville, N.Y.). 46 (1): 17–27. doi:10.1016/j.alcohol.2011.08.011. PMC 4581853. PMID 21962974.
2. Shaw WN, et al. (Jun 1991). "The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat". International Journal of Obesity. 15 (6): 387–95. PMID 1653188.