LTN1

Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 gene.^[5]

LTN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J92
Identifiers
Aliases	LTN1, C21orf10, C21orf98, RNF160, ZNF294, listerin E3 ubiquitin protein ligase 1
External IDs	OMIM: 613083; MGI: 1926163; HomoloGene: 32272; GeneCards: LTN1; OMA:LTN1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 28,928,144 bp[1] End 28,992,956 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 87,173,539 bp[2] End 87,229,500 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte decidua biceps brachii endothelial cell mucosa of sigmoid colon Skeletal muscle tissue of biceps brachii skin of thigh skin of hip Skeletal muscle tissue of rectus abdominis tail of epididymis Top expressed in cumulus cell seminiferous tubule lacrimal gland substantia nigra pineal gland parotid gland spermatid seminal vesicula ascending aorta aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity ribosomal large subunit binding Cellular component cytosol RQC complex Biological process protein ubiquitination protein autoubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process rescue of stalled ribosome ribosome-associated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26046 78913 Ensembl ENSG00000198862 ENSMUSG00000052299 UniProt O94822 Q6A009 RefSeq (mRNA) NM_015565 NM_001320766 NM_001081068 RefSeq (protein) NP_001307695 NP_056380 NP_001074537 Location (UCSC) Chr 21: 28.93 – 28.99 Mb Chr 16: 87.17 – 87.23 Mb PubMed search [3] [4]
Wikidata
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Function

Like most RING finger proteins, listerin functions as an E3 ubiquitin ligase.^[6] Listerin is a component of the ribosome quality control complex.^[7][8]