LTN1

Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 gene.^[5]

LTN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J92
Identifiers
Aliases	LTN1, C21orf10, C21orf98, RNF160, ZNF294, listerin E3 ubiquitin protein ligase 1
External IDs	OMIM: 613083; MGI: 1926163; HomoloGene: 32272; GeneCards: LTN1; OMA:LTN1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 28,928,144 bp[1] End 28,992,956 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 87,173,539 bp[2] End 87,229,500 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte decidua biceps brachii endothelial cell mucosa of sigmoid colon Skeletal muscle tissue of biceps brachii skin of thigh skin of hip Skeletal muscle tissue of rectus abdominis tail of epididymis Top expressed in cumulus cell seminiferous tubule lacrimal gland substantia nigra pineal gland parotid gland spermatid seminal vesicula ascending aorta aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity ribosomal large subunit binding Cellular component cytosol RQC complex Biological process protein ubiquitination protein autoubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process rescue of stalled ribosome ribosome-associated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26046 78913 Ensembl ENSG00000198862 ENSMUSG00000052299 UniProt O94822 Q6A009 RefSeq (mRNA) NM_015565 NM_001320766 NM_001081068 RefSeq (protein) NP_001307695 NP_056380 NP_001074537 Location (UCSC) Chr 21: 28.93 – 28.99 Mb Chr 16: 87.17 – 87.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Like most RING finger proteins, listerin functions as an E3 ubiquitin ligase.^[6] Listerin is a component of the ribosome quality control complex.^[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000198862 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052299 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Listerin E3 ubiquitin protein ligase 1".
6. Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA (February 2009). "A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 106 (7): 2097–103. doi:10.1073/pnas.0812819106. PMC 2650114. PMID 19196968.
7. Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.
8. Shao S, von der Malsburg K, Hegde RS (June 2013). "Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation". Molecular Cell. 50 (5): 637–48. doi:10.1016/j.molcel.2013.04.015. PMC 3719020. PMID 23685075.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.