LTBP1 (gene)

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

LTBP1 (gene)

Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.[5][6][7]

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LTBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLTBP1, latent transforming growth factor beta binding protein 1
External IDsOMIM: 150390; MGI: 109151; HomoloGene: 522; GeneCards: LTBP1; OMA:LTBP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000627
NM_001166264
NM_001166265
NM_001166266
NM_206943

RefSeq (protein)

NP_000618
NP_001159736
NP_001159737
NP_001159738
NP_996826

Location (UCSC)Chr 2: 32.95 – 33.4 MbChr 17: 75.31 – 75.7 Mb
PubMed search[3][4]
Wikidata
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The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

Interactions

LTBP1 (gene) has been shown to interact with TGF beta 1.[8]

References

Further reading

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