LRP1B

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.^[5][6]

LRP1B
Identifiers
Aliases	LRP1B, LRP-DIT, LRPDIT, LDL receptor related protein 1B, LRP-1B
External IDs	OMIM: 608766; MGI: 2151136; HomoloGene: 56810; GeneCards: LRP1B; OMA:LRP1B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q22.1-q22.2 Start 140,231,423 bp[1] End 142,131,016 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 40,485,258 bp[2] End 42,543,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 Region I of hippocampus proper Skeletal muscle tissue of rectus abdominis glutes testicle prefrontal cortex primary visual cortex anterior cingulate cortex Amygdala Top expressed in zygote facial motor nucleus dentate gyrus dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord dorsal striatum superior frontal gyrus primary visual cortex ventromedial nucleus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane receptor complex membrane Biological process protein transport endocytosis receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53353 94217 Ensembl ENSG00000168702 ENSMUSG00000049252 UniProt Q9NZR2 Q9JI18 RefSeq (mRNA) NM_018557 NM_053011 RefSeq (protein) NP_061027 n/a Location (UCSC) Chr 2: 140.23 – 142.13 Mb Chr 2: 40.49 – 42.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.^[7]