LRP1B

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.^[5][6]

LRP1B
Identifiers
Aliases	LRP1B, LRP-DIT, LRPDIT, LDL receptor related protein 1B, LRP-1B
External IDs	OMIM: 608766; MGI: 2151136; HomoloGene: 56810; GeneCards: LRP1B; OMA:LRP1B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q22.1-q22.2 Start 140,231,423 bp[1] End 142,131,016 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 40,485,258 bp[2] End 42,543,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 Region I of hippocampus proper Skeletal muscle tissue of rectus abdominis glutes testicle prefrontal cortex primary visual cortex anterior cingulate cortex Amygdala Top expressed in zygote facial motor nucleus dentate gyrus dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord dorsal striatum superior frontal gyrus primary visual cortex ventromedial nucleus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane receptor complex membrane Biological process protein transport endocytosis receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53353 94217 Ensembl ENSG00000168702 ENSMUSG00000049252 UniProt Q9NZR2 Q9JI18 RefSeq (mRNA) NM_018557 NM_053011 RefSeq (protein) NP_061027 n/a Location (UCSC) Chr 2: 140.23 – 142.13 Mb Chr 2: 40.49 – 42.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168702 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049252 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines". Cancer Res. 60 (7): 1961–7. PMID 10766186.
6. "Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)".
7. Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID 11384978.

Further reading

• Liu CX, Musco S, Lisitsina NM, et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics. 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID 11031110.
• Langbein S, Szakacs O, Wilhelm M, et al. (2002). "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer". Lab. Invest. 82 (5): 639–43. doi:10.1038/labinvest.3780458. PMID 12004004.
• Li Y, Knisely JM, Lu W, et al. (2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration". J. Biol. Chem. 277 (44): 42366–71. doi:10.1074/jbc.M207705200. PMID 12194987.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cam JA, Zerbinatti CV, Knisely JM, et al. (2004). "The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production". J. Biol. Chem. 279 (28): 29639–46. doi:10.1074/jbc.M313893200. PMID 15126508.
• Tanaga K, Bujo H, Zhu Y, et al. (2005). "LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1422–8. doi:10.1161/01.ATV.0000133607.80554.09. PMID 15166012.
• Sonoda I, Imoto I, Inoue J, et al. (2004). "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma". Cancer Res. 64 (11): 3741–7. doi:10.1158/0008-5472.CAN-04-0172. PMID 15172977. S2CID 12527714.
• Li Y, Lu W, Bu G (2005). "Striking differences of LDL receptor-related protein 1B expression in mouse and human". Biochem. Biophys. Res. Commun. 333 (3): 868–73. doi:10.1016/j.bbrc.2005.05.170. PMID 15963947.
• Pastrana DV, Hanson AJ, Knisely J, et al. (2006). "LRP 1 B functions as a receptor for Pseudomonas exotoxin". Biochim. Biophys. Acta. 1741 (3): 234–9. doi:10.1016/j.bbadis.2005.06.007. PMID 16095885.
• Nakagawa T, Pimkhaokham A, Suzuki E, et al. (2006). "Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma". Cancer Sci. 97 (10): 1070–4. doi:10.1111/j.1349-7006.2006.00283.x. PMC 11159176. PMID 16918994. S2CID 30699151.
• Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells". J. Biol. Chem. 282 (10): 7504–11. doi:10.1074/jbc.M608088200. PMID 17227771.