LRIG1

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.^[5][6][7] It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family^[8] and with MET^[9] and RET.^[10]

LRIG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4U7L, 4U7M
Identifiers
Aliases	LRIG1, LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1
External IDs	OMIM: 608868; MGI: 107935; HomoloGene: 7380; GeneCards: LRIG1; OMA:LRIG1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.1 Start 66,378,797 bp[1] End 66,501,263 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D2|6 43.15 cM Start 94,581,510 bp[2] End 94,677,139 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte bronchial epithelial cell ventricular zone body of pancreas cardia gastric mucosa muscle layer of sigmoid colon pylorus internal globus pallidus lactiferous duct Top expressed in muscle of thigh lip ventricular zone dentate gyrus of hippocampal formation granule cell cerebellar cortex zygote secondary oocyte superior frontal gyrus tail of embryo esophagus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 26018 16206 Ensembl ENSG00000144749 ENSMUSG00000030029 UniProt Q96JA1 P70193 RefSeq (mRNA) NM_015541 NM_008377 NM_001355269 RefSeq (protein) NP_056356 NP_001364273 NP_001364274 NP_001364275 NP_001364276 NP_001364277 NP_001364278 NP_032403 NP_001342198 Location (UCSC) Chr 3: 66.38 – 66.5 Mb Chr 6: 94.58 – 94.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000144749 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030029 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H (Jun 2001). "Cloning, characterization, and expression of human LIG1". Biochem Biophys Res Commun. 284 (5): 1155–61. doi:10.1006/bbrc.2001.5092. PMID 11414704.
6. Hedman H, Nilsson J, Guo D, Henriksson R (Sep 2002). "Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?". Acta Oncol. 41 (4): 352–4. doi:10.1080/028418602760169398. PMID 12234026. S2CID 34357648.
7. "Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1".
8. Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549.
9. Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829.
10. Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G (2008). "Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF". J. Neurosci. 28 (2): 39–49. doi:10.1523/JNEUROSCI.2196-07.2008. PMC 6671136. PMID 18171921.

Further reading

• Suzuki Y, Sato N, Tohyama M, et al. (1996). "cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains". J. Biol. Chem. 271 (37): 22522–7. doi:10.1074/jbc.271.37.22522. PMID 8798419.
• Suzuki Y, Miura H, Tanemura A, et al. (2002). "Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia". FEBS Lett. 521 (1–3): 67–71. doi:10.1016/S0014-5793(02)02824-7. PMID 12067728. S2CID 5634836.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nilsson J, Starefeldt A, Henriksson R, Hedman H (2004). "LRIG1 protein in human cells and tissues". Cell Tissue Res. 312 (1): 65–71. doi:10.1007/s00441-003-0697-1. PMID 12684867. S2CID 7060595.
• Thomasson M, Hedman H, Guo D, et al. (2003). "LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis". Br. J. Cancer. 89 (7): 1285–9. doi:10.1038/sj.bjc.6601208. PMC 2394322. PMID 14520461.
• Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549.
• Laederich MB, Funes-Duran M, Yen L, et al. (2004). "The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases". J. Biol. Chem. 279 (45): 47050–6. doi:10.1074/jbc.M409703200. PMID 15345710.{{cite journal}}: CS1 maint: numeric names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ljuslinder I, Malmer B, Golovleva I, et al. (2006). "Increased copy number at 3p14 in breast cancer". Breast Cancer Res. 7 (5): R719–27. doi:10.1186/bcr1279. PMC 1242137. PMID 16168117.
• Jensen KB, Watt FM (2006). "Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence". Proc. Natl. Acad. Sci. U.S.A. 103 (32): 11958–63. Bibcode:2006PNAS..10311958J. doi:10.1073/pnas.0601886103. PMC 1567680. PMID 16877544.
• Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829.